Ernst Th. Rietschel

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How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors — the Toll-like receptors — was rooted in chemical, biological and genetic(More)
Recognition of LPS, one of the most potent prokaryotic stimulators of immune and non-immune cells of higher organisms, appears to be a complex and highly differentiated process. In CD14-positive cells a model involving two major elements for LPS recognition and uptake, i.e. LBP and cellular CD14, is becoming apparent. The involvement of LBP in the(More)
The complex formation of lipopolysaccharide (LPS) with chitosan (Ch) was demonstrated using sedimentation velocity analysis in the analytical ultracentrifuge, centrifugation in glycerol gradient and isopicnic centrifugation in cesium chloride. An addition of Ch to the Escherichia coli and Yersinia pseudotuberculosis LPS solutions was found to result in(More)
The classical concept of the architecture of microbial murein assumes cross-linked glycan chains to be arranged in horizontal layers outside of the plasma membrane. It necessitates elaborate hypotheses to explain processes such as the biosynthesis, growth and division of the bacterial cell wall and provides no explanation for transenvelope macromolecular(More)
Today a great number of problems in the field of bacterial sepsis remain to be solved. Understanding the molecular mechanisms of one of the most important bacterial products in the pathogenesis of sepsis – endotoxin – may contribute to innovative and more effective therapies. Therefore, this review focuses on the structural and functional elements of(More)
Although the chemical structure and physical properties of peptidoglycan have been elucidated for some time, the precise three-dimensional organization of murein has remained elusive. Earlier published computer simulations of the bacterial murein architecture modeled peptidoglycan strands in either a regular (D. Pink, J. Moeller, B. Quinn, M. Jericho, and(More)
Purified fractions from a fetal sheep liver extract (FSLE) were investigated, in a murine model, for induction of leukocyte stimulating activities. The fractions FSLE-1 and FSLE-2 induced splenocyte proliferation in vitro in C57Bl/10ScSn (LPS responder) mice comparable to LPS, and in C57Bl/10ScCr (LPS non responder) mice. They also stimulated the release of(More)
From 06/02/97 until 08/29/97, I was working at the division of Molecular Medicine at the North Shore University Hospital/Cornell University Medical College in New York on a research project concerning the role of CD14 in a chronic Gram-negative experimental infection model. On the one hand I had to accept three months absence from my family and my own(More)