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The production and action of immunoregulatory cytokines, including interleukin-1 (IL-1), are inhibited by glucocorticoid hormones in vivo and in vitro. Conversely, glucocorticoid blood levels were… Continue Reading
In order to bring the self-regulated immune system into conformity with other body systems its functioning within the context of an immune-neuroendocrine network is proposed. This hypothesis is based… Continue Reading
Abstract A postulated immunoregulatory role for the autonomous nervous system was explored utilizing several in vivo and in vitro approaches. Local surgical denervation of the spleen in rats and… Continue Reading
The immune system is subject to an array of identified autoregulatory processes, but immunoregulation may also have a further basis in a network of immune-neuroendocrine interactions. Two antigens… Continue Reading
THE suggestion that ageing may depend on immunological disorders1–6 has been prompted by observations that organs and physiological systems show wide differences in the time they need to use up their… Continue Reading
Concepts and facts concerning immune-neuroendocrine interactions are discussed. The immune response elicits endocrine, autonomic, and brain functional changes. These changes can be mediated by… Continue Reading