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PURPOSE Intestinal non-Hodgkin's lymphomas are not well characterized. We therefore studied prospectively their clinical features and response to standardized therapy. PATIENTS AND METHODS Fifty-six patients with primary intestinal lymphoma were included in a prospective, nonrandomized multicenter study. Lymphoma resection was recommended and staging was… (More)
BACKGROUND & AIMS Collagenous sprue (CS) is a rare severe malabsorption syndrome of unknown etiology, characterized by villus atrophy and a broad subepithelial collagen band. We studied the expression patterns of genes involved in fibrogenesis and fibrolysis and analyzed the composition of the subepithelial collagen band in CS compared with untreated celiac… (More)
The expression of the carbohydrate antigen sialyl-Le(x) and of the oncogenes c-myc and Ki-ras increases after malignant transformation of the colorectum. Since the overexpression of these two oncogenes may affect O- or N-linked carbohydrate chain synthesis, we investigated if this is the case for sialyl-Le(x). In parallel sections from 11 adenomas and 9… (More)
BACKGROUND Autoimmune enteropathy is a life-threatening, chronic disease of the small bowel mucosa, which generally responds well to steroids. Treatment requires long-term immunosuppression, and steroid-sparing treatment strategies are desirable. Azathioprine and cyclosporine A have limitations, however alternatives have not been described in adults. CASE… (More)
SUMMARY The present study was undertaken to determine the influence of hyperphagia on the adaptive changes occurring in the rat jejunal mucosa as a result of intestinal resection. One group of resected rats was subjected to pair feeding with a sham-operated population, whilst another group was nourished ad libitum. The animals which ate ad libitum developed… (More)
Three issues pertaining to the association between surgery and gastroenterology in Germany have been addressed: what is the present situation; what questions arise regarding the needs of patients; and what has been undertaken so far to overcome these difficulties.