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Event-related functional MRI (fMRI) was used to study blood oxygen level dependent cortical signal changes associated with volitional limb movements off and on levodopa in Parkinson's disease. Eight patients with early stage akinetic Parkinson's disease and eight healthy volunteers underwent three functional imaging runs (high speed echo planar imaging with(More)
Neuroimaging studies with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) have delineated a human pain network in vivo. Despite the recognition of cerebral structures engaged in pain transmission, the cerebral mechanisms involved in pain modulation are still not well understood. Here, we investigated healthy volunteers(More)
The aim of this study was to determine apparent diffusion coefficients (ADCs) of focal liver lesions on the basis of a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging sequence (DW-SS-EPI) and to evaluate whether ADC measurements can be used to characterize lesions. One hundred and two patients with focal liver lesions [11(More)
UNLABELLED The recently introduced first integrated whole-body PET/MR scanner allows simultaneous acquisition of PET and MRI data in humans and, thus, may offer new opportunities, particularly regarding diagnostics in oncology. This scanner features major technologic differences from conventional PET/CT devices, including the replacement of photomultipliers(More)
To evaluate the capacity of human monocytes to phagocytose various approved iron oxide based magnetic resonance (MR) contrast agents and to optimize in vitro labeling of these cells. Human monocytes were incubated with two superparamagnetic iron oxide particles (SPIO) as well as two ultrasmall SPIO (USPIO) at varying iron oxide concentrations and incubation(More)
PURPOSE To evaluate respiratory-triggered diffusion-weighted MR imaging (DWI) in the characterization of small (≤10 mm) focal liver lesions (FLL). MATERIALS AND METHODS A total of 185 FLL (76 metastases, 11 HCCs, 71 cysts, 18 hemangiomas, 6 focal nodular hyperplasias, 3 adenomas) were retrospectively analyzed in 77 patients. DWI was performed at 1.5 T(More)
To evaluate the performance of experienced versus inexperienced radiologists in comparison and in consensus with an interactive computer-aided detection (CAD) system for detection of pulmonary nodules. Eighteen consecutive patients (mean age: 62.2 years; range 29–83 years) prospectively underwent routine 16-row multislice computed tomography (MSCT). Four(More)
OBJECTIVE The number of CT examinations is increasing relatively dramatically, hence the radiation dose of the associated population. Thus, there is a need for efficient reconstruction methods with dose reduction potential that also maintain the image quality. In this article, we present the initial performance evaluation of such a reconstruction algorithm(More)
PURPOSE To evaluate, both experimentally and in vivo, if nondedicated standard spiral computed tomography (CT) may be used to obtain reliable bone mineral density (BMD) data. MATERIALS AND METHODS Twenty lumbar spine specimens from human cadavers were examined with standard quantitative CT and spiral CT. In addition, 50 patients with a history of lymphoma(More)
OBJECTIVE The purpose of this study was to evaluate the diagnostic performance of MR arthrography in the assessment of superior labral anteroposterior (SLAP) lesions of the shoulder with emphasis on the classification of SLAP lesions. MATERIALS AND METHODS Two hundred sixty-five MR arthrograms including 68 MR arthrograms of patients with arthroscopically(More)