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By induction of a graft-vs.-host reaction (GVHR) in nonirradiated H-2-different F1 mice, one can induce stimulatory pathological symptoms, such as lymphadenopathy and hypergammaglobulinemia, combined with the production of autoantibodies characteristic of systemic lupus erythematosus (SLE). Alternatively, the GVHR can lead to the suppressive pathological(More)
In experimentally exposed animals 2,3,7,8-tetrachlorodibenzo-n-dioxin (TCDD) causes severe immunosuppression. However, the overall susceptibility of humans for the different pathological effects of TCDD has remained unclear. We examined the long-term effects of TCDD in 11 industrial workers who were exposed to high doses of TCDD for several years 20 years(More)
The graft-vs.-host reaction (GVHR) 1 is initiated by immune responses of donor T lymphocytes to allogeneic histocompatibility antigens of the recipient. These initial reactions cause a chain of complex and sometimes antagonistic events that can result in various pathological symptoms. One possible outcome of the GVHR is acute GVH disease (GVHD). It is(More)
One of the possible consequences of the graft-versus-host reaction (GVHR) 1 in animals and man is runt disease or acute graft-versus-host (GVH) disease (GVHD). It is frequently fatal and produces a variety of symptoms, which include atrophy of the skin and the gastrointestinal mucosa and hypoplasia of the hemopoietic and lymphoid tissues manifested by(More)
We studied the alloreactive properties of donor T cells obtained from F1 mice that had recovered from the allosuppression of acute graft-vs.-host disease (GVHD) and showed mild symptoms of chronic GVHD, i.e., so-called secondary chronic GVHD. To this end, we used (B10 x DBA/2)F1 mice that had been injected with 10(8) B10 spleen cells 100-150 d previously.(More)
The role of hypochlorite ion, which can be generated by the enzyme myleoperoxidase, in the biochemistry of gold(I) anti-arthritic drugs was investigated. Sodium hypochlorite (OCl(-)) directly and rapidly oxidizes AuSTm, Au(CN)(2) (-), AuSTg (gold thioglucose) and auranofin (Et(3)PAuSATg). The resulting gold(III) species were detected by an Ion(More)
The pathogenic significance of the increased association of systemic lupus erythem-atosus (SLE) with certain structures of the major histocompatibility complex (MHC) (1-4) is unknown. An experimental model of SLE, in which MHC structures play a defined pathogenic role, is the induction of an SLE-like graft-vs.-host reaction (GVHR) in nonirradiated F1 mice(More)
Three new findings are reviewed that help to understand the mechanisms of action of antirheumatic Au(I) drugs, such as disodium aurothiomalate (Na(2)Au(I)TM): (i) We found that Na(2)Au(I)TM selectively inhibits T cell receptor (TCR)-mediated antigen recognition by murine CD(4+) T cell hybridomas specific for antigenic peptides containing at least two(More)
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