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  • M Degli Esposti, Anna Ghelli, Marina Ratta, Diego Alves Côrtes, Ernesto Estornell
  • Biology, Medicine
  • The Biochemical journal
  • 1994 (First Publication: 1 July 1994)
  • Natural products from the plants of the family Annonaceae, collectively called Annonaceous acetogenins, are very potent inhibitors of the NADH-ubiquinone reductase (Complex I) activity of mammalianContinue Reading
    The reduction kinetics of coenzyme Q (CoQ, ubiquinone) by NADH:ubiquinone oxidoreductase (complex I, EC 1.6.99.3) was investigated in bovine heart mitochondrial membranes using water-soluble homologsContinue Reading
  • Jose R Tormo, Teresa Escrich Gallardo, R. Aragón, Diego Alves Côrtes, Ernesto Estornell
  • Chemistry, Medicine
  • Chemico-biological interactions
  • 1999 (First Publication: 1 October 1999)
  • Annonaceous acetogenins (ACG) are a wide group of cytotoxic compounds isolated from plants of the Annonaceae family. Some of them are promising candidates to be a future new generation of antitumorContinue Reading
  • Ernesto Estornell, Romana Fato, Cinzia Castelluccio, Marika Cavazzoni, Giovanna Parenti Castelli, Giorgio Lenaz
  • Medicine, Biology
  • FEBS letters
  • 1992 (First Publication: 19 October 1992)
  • The saturation kinetics of NADH and succinate oxidation for Coenzyme Q (CoQ) has been re-investigated in pentane-extracted lyophilized beef heart mitochondria reconstituted with exogenous CoQ10. TheContinue Reading
  • M Degli Esposti, Anna Ghelli, Massimo Crimi, Ernesto Estornell, Romana Fato, Giorgio Lenaz
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 1993 (First Publication: 1 February 1993)
  • Mitochondrial complex I and complex III have common inhibitors with ubiquinone-like structure. The tridecyl analog of stigmatellin, which inhibits mitochondrial complex III at nanomolarContinue Reading
    Annonaceous acetogenins (ACG) are a large family of natural products that have been described as the most potent in vitro inhibitors of the mitochondrial respiratory chain Complex I. During the lastContinue Reading