Ernest Newbrun

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Studies of special population groups, epidemiological surveys, controlled longitudinal studies of humans, and longitudinal studies on the effect of sugar substitutes indicate that frequent or high intake of sugary foods predisposes to dental decay. The relation is not always clear-cut, and most studies have important methodological problems and limitations.(More)
A trypsin-like, membrane-bound protease from Bacteroides gingivalis was solubilized by Triton X-100 and partially purified by a combination of DEAE-Sepharose and aminophenylmercuric Sepharose chromatography, by taking advantage of the thiol group on the enzyme. The purified enzyme hydrolysed the synthetic substrates benzoyl-L-arginine-p-nitroanilide(More)
Acarbose is known to inhibit glucoamylase, maltase and sucrase. Our aim was to test whether it would also inhibit glucosyltransferase (GTF), to determine the type of inhibition and to compare the inhibitor potency of acarbose with that of nojirimycin and deoxynojirimycin, two other glucosidase inhibitors. Enzyme inhibition was measured either by chemical(More)
There is much that we know about fluoride as it relates to human health in general and dental health in particular. Some of the information that is known concerning water fluoridation and dental fluorosis is listed. What we do not know about fluoride is discussed in more detail, namely the efficacy of lower levels of fluoride in drinking water, the effect(More)
Persons with HFI follow a lifelong, self-imposed, sucrose-restricted diet in which foods containing sucrose are consumed infrequently. Our subjects with HFI had a total sucrose intake that was approximately 5% that of control subjects and had a caries score (DMFS) that was less than 10% that of control subjects. No significant differences were found in the(More)
A review of evidence-based literature indicates incomplete evidence for the efficacy of most measures currently used for caries prevention, with the exception of fluoride varnishes and the use of fluoride-based interventions for patients with hyposalivation. Not all fluoride agents and treatments are equal. Different fluoride compounds, different vehicles,(More)
In recent years, an increase in the prevalence of dental fluorosis, mostly of the very mild to mild category, has been seen in the United States. This paper therefore discusses the safety of dental fluoride products, primarily with respect to the risk of dental fluorosis due to chronic ingestion of these products by pre-school children. No change is(More)
Behavior of patients with autistic syndrome makes delivery of oral hygiene and dental treatment a problem. In this study, the oral health and needs of two groups of patients with autism were evaluated: noninstitutionalized children with a mean age of 11 and institutionalized adults with a mean age of 22. The latter group had severe periodontal problems;(More)
Communal water fluoridation is not considered controversial by the vast majority of the scientific community; however, politically it has persisted as an issue that many legislators and community leaders have avoided because of an aura of dispute, it has been a battleground for vigorous opposition by a very small but outspoken minority who have fought it(More)