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BACKGROUND The intact parathyroid hormone (PTH) assay evaluates levels of serum 1-84 PTH and other N-terminally truncated PTH fragments, mainly PTH "7-84." This PTH molecule has been found experimentally to interfere with biological activity of PTH 1-84, perhaps through its binding to the PTH receptor complex. Therefore, assuming that high levels of PTH(More)
Osteonectin was immunolocalized in human fetal and calf neonatal developing bone using newly developed monoclonal antibodies. The protein was localized to the cytoplasm of osteoblasts and young osteocytes. In bone matrix, strong reactivity was found in newly laid down osteoid. Bone matrix immunoreactivity was enhanced by pretreatment of sections with(More)
The organic/inorganic relationships in calcifying cartilage have been studied in tibialfemoral epiphyses of 5-day-old rats and in costochondral junctions of 1-month-old guinea pigs. The main results are: (a) Apatite crystallites in areas of early cartilage calcification are easily removed from araldite and glycol methacrylate (GMA) sections by 1-hour(More)
We defined two distinct maturational compartments (proliferative and secretory) of osteogenic cells in vivo on the basis of ALP activity, BrdU incorporation, cell shape, and BSP production. BSP immunoreactivity was found to mark cells in the secretory but not in the proliferative compartment. We established the phenotypic similarity of primitive marrow(More)
The cartilage matrix in which the early calcium salts are deposited has been studied in the tibial epiphyses and in the costo-chondral junctions of 30-day-old guinea pigs. The results may be summarized as follows: (1) Structures of globular shape (“globules”) are to be found throughout the entire epiphyseal plate. (2) They have a homogeneous matrix and are(More)