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Pyrethroids and Their Effects on Ion Channels
Ion channels are integral membrane proteins that are critical for neuronal function. They form pores in the plasma membrane that allow certain ions to travel with their concentration gradient across… Expand
scAAV9 intracisternal delivery results in efficient gene transfer to the central nervous system of a feline model of motor neuron disease.
On the basis of previous studies suggesting that vascular endothelial growth factor (VEGF) could protect motor neurons from degeneration, adeno-associated virus vectors (serotypes 1 and 9) encoding… Expand
Failure of lower motor neuron radial outgrowth precedes retrograde degeneration in a feline model of spinal muscular atrophy
- Erin N Wakeling, B. Joussemet, +4 authors J. Fyfe
- Biology, Medicine
- The Journal of comparative neurology
- 1 June 2012
Feline spinal muscular atrophy (SMA) is a fully penetrant, autosomal recessive lower motor neuron disease in domestic cats that clinically resembles human SMA Type III. A whole genome linkage scan… Expand
Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
Feline spinal muscular atrophy (SMA) is an autosomal recessive juvenile onset lower motor neuron disease caused by an ∼ 140 kb deletion that disrupts expression of 2 genes, limb expression 1 (LIX1)… Expand
Different Clonal T-Large Granular Lymphocyte Proliferations in SCID
- S. Savaşan, Erin N Wakeling, T. Knight, S. Buck, Manisha Gadgeel
- Biology, Medicine
- Journal of Clinical Immunology
- 27 March 2019
To The Editor: Large granular lymphocytes (LGLs) are morphologically defined cells containing small numbers of discretely recognizable granules when examined under the microscope. They can belong to… Expand
Towards early personalized patient management: Molecular classification of endometrial carcinoma applied to endometrial biopsy specimens