Erin Lincoln | Semantic Scholar

Publications
Influence

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IL-27 mediates complete regression of orthotopic primary and metastatic murine neuroblastoma tumors: role for CD8+ T cells.

Rosalba Salcedo, Jimmy K. Stauffer, +7 authors Jon M. Wigginton
Journal of immunology
2004

We have shown previously that IFN-gamma-inducing cytokines such as IL-12 can mediate potent antitumor effects against murine solid tumors. IL-27 is a newly described IL-12-related cytokine that… (More)

Immunologic and therapeutic synergy of IL-27 and IL-2: enhancement of T cell sensitization, tumor-specific CTL reactivity and complete regression of disseminated neuroblastoma metastases in the liver…

Rosalba Salcedo, Julie A. Hixon, +15 authors Jon M. Wigginton
Journal of immunology
2009

IL-27 exerts antitumor activity in murine orthotopic neuroblastoma, but only partial antitumor effect in disseminated disease. This study demonstrates that combined treatment with IL-2 and IL-27… (More)

Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.

Tahira Khan, Jimmy K. Stauffer, +9 authors Jon M. Wigginton
Journal of immunology
2004

Human neuroblastomas possess several mechanisms of self-defense that may confer an ability to resist apoptosis and contribute to the observed difficulty in treating these tumors in the clinical… (More)

Multicolor fluorescence-based approaches for imaging cytokine-induced alterations in the neovascularization, growth, metastasis, and apoptosis of murine neuroblastoma tumors.

Jimmy K. Stauffer, Tahira Khan, +4 authors Jon M. Wigginton
Journal of immunotherapy
2006

Neuroblastoma is one of the most common solid tumors in children. The prognosis of patients with advanced neuroblastoma is poor overall despite standard therapeutic modalities and has stimulated… (More)

Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma.

Tahira Khan, Julie A. Hixon, +7 authors Jon M. Wigginton
Journal of the National Cancer Institute
2006

BACKGROUND Patients with advanced neuroblastoma have a poor prognosis. The antiapoptotic protein Akt has been implicated as a possible mediator of the resistance of human neuroblastoma cells to… (More)

High-throughput molecular and histopathologic profiling of tumor tissue in a novel transplantable model of murine neuroblastoma: new tools for pediatric drug discovery.

Jimmy K. Stauffer, Rimas Orentas, +14 authors Jon M. Wigginton
Cancer investigation
2012

Using two MYCN transgenic mouse strains, we established 10 transplantable neuroblastoma cell lines via serial orthotopic passage in the adrenal gland. Tissue arrays demonstrate that by… (More)

Antidysrhythmics in,Cardiac Arrest: What Does the Literature Say? Several have come and gone-what's the basis for using those still in our arsenal?

EMS, Quality Improvement Programs

IL-18 Induces Complete Regression of Orthotopic Primary and Metastatic Murine Neuroblastoma Tumors and Potentiates Antitumor Immune Reactivity in Combination with IL-2

275 Interleukin-12 inhibits AKT phosphorylation and upregulates cleavage and subcellular translocation of EGFP-bid within murine neuroblastoma tumors

Jon M. Wigginton, Julie A. Hixon, +6 authors Tahira Khan
2004