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- Publications
- Influence
IL-27 Mediates Complete Regression of Orthotopic Primary and Metastatic Murine Neuroblastoma Tumors: Role for CD8+ T Cells1
- R. Salcedo, Jimmy K. Stauffer, +7 authors J. Wigginton
- Biology, Medicine
- The Journal of Immunology
- 15 December 2004
We have shown previously that IFN-γ-inducing cytokines such as IL-12 can mediate potent antitumor effects against murine solid tumors. IL-27 is a newly described IL-12-related cytokine that… Expand
Immunologic and Therapeutic Synergy of IL-27 and IL-2: Enhancement of T Cell Sensitization, Tumor-Specific CTL Reactivity and Complete Regression of Disseminated Neuroblastoma Metastases in the Liver…
- R. Salcedo, J. Hixon, +15 authors J. Wigginton
- Medicine
- The Journal of Immunology
- 1 April 2009
IL-27 exerts antitumor activity in murine orthotopic neuroblastoma, but only partial antitumor effect in disseminated disease. This study demonstrates that combined treatment with IL-2 and IL-27… Expand
Proteasome inhibition to maximize the apoptotic potential of cytokine therapy for murine neuroblastoma tumors.
- Tahira Khan, Jimmy K. Stauffer, +9 authors J. Wigginton
- Medicine
- Journal of immunology
- 1 November 2004
Human neuroblastomas possess several mechanisms of self-defense that may confer an ability to resist apoptosis and contribute to the observed difficulty in treating these tumors in the clinical… Expand
Therapeutic modulation of Akt activity and antitumor efficacy of interleukin-12 against orthotopic murine neuroblastoma.
- Tahira Khan, J. Hixon, +7 authors J. Wigginton
- Biology, Medicine
- Journal of the National Cancer Institute
- 1 February 2006
BACKGROUND
Patients with advanced neuroblastoma have a poor prognosis. The antiapoptotic protein Akt has been implicated as a possible mediator of the resistance of human neuroblastoma cells to… Expand
Proteasome Inhibition to Maximize the Apoptotic Potential of Cytokine Therapy for Murine Neuroblastoma Tumors1
- T. Khan, Jimmy K. Stauffer, +9 authors J. Wigginton
- Biology
- The Journal of Immunology
- 15 May 2006
Human neuroblastomas possess several mechanisms of self-defense that may confer an ability to resist apoptosis and contribute to the observed difficulty in treating these tumors in the clinical… Expand
High-Throughput Molecular and Histopathologic Profiling of Tumor Tissue in a Novel Transplantable Model of Murine Neuroblastoma: New Tools for Pediatric Drug Discovery
- Jimmy K. Stauffer, R. Orentas, +14 authors J. Wigginton
- Biology, Medicine
- Cancer investigation
- 10 May 2012
Using two MYCN transgenic mouse strains, we established 10 transplantable neuroblastoma cell lines via serial orthotopic passage in the adrenal gland. Tissue arrays demonstrate that by… Expand
Multicolor Fluorescence-Based Approaches for Imaging Cytokine-Induced Alterations in the Neovascularization, Growth, Metastasis, and Apoptosis of Murine Neuroblastoma Tumors
- Jimmy K. Stauffer, T. Khan, +4 authors J. Wigginton
- Biology, Medicine
- Journal of immunotherapy
- 1 March 2006
Neuroblastoma is one of the most common solid tumors in children. The prognosis of patients with advanced neuroblastoma is poor overall despite standard therapeutic modalities and has stimulated… Expand
Antidysrhythmics in,Cardiac Arrest: What Does the Literature Say? Several have come and gone-what's the basis for using those still in our arsenal?
- Jeffrey L. Jarvis, Erin Lincoln
- Medicine
- EMS world
- 1 February 2017