Erin L McArdle

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STUDY DESIGN This study demonstrated the diagnostic potential of sodium (Na) magnetic resonance imaging (MRI) for noninvasive quantification of proteoglycan (PG) in the intervertebral discs. OBJECTIVE To determine the existence of a linear correlation between intervertebral disc [Na] measured from sodium MRI and [PG] measurement from DMMB assay. SUMMARY(More)
Nine asymptomatic subjects and six patients underwent T(1)rho MRI to determine whether Outerbridge grade 1 or 2 cartilage degeneration observed during arthroscopy could be detected noninvasively. MRI was performed 2-3 months postarthroscopy, using sagittal T(1)-weighted and axial and coronal T(1)rho MRI, from which spatial T(1)rho relaxation maps were(More)
BACKGROUND The need of an early and noninvasive diagnosis of AD requires the development of imaging-based techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer's disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values(More)
PURPOSE To evaluate the T1rho (T(1rho)) MRI relaxation time in hippocampus in the brain of Alzheimer's disease (AD), mild cognitive impairment (MCI), and control, and to determine whether the T(1rho) shows any significant difference between these cohorts. MATERIALS AND METHODS With informed consent, AD (n = 49), MCI (n = 48), and age-matched control (n =(More)
A spin-locked balanced steady-state free-precession (slSSFP) pulse sequence is described that combines a balanced gradient-echo acquisition with an off-resonance spin-lock pulse for fast MRI. The transient and steady-state magnetization trajectory was solved numerically using the Bloch equations and was shown to be similar to balanced steady-state(More)
M. Haris, E. McArdle, M. Sochor, M. Fenty, A. Singh, C. Davatzikos, J. Q. Trojanowski, E. R. Melhem, C. M. Clark, R. Reddy, and A. Borthakur MMRRCC, Radiology, University of Pennsylvania, Philadephia, PA, United States, SBIA, Radiology, University of Pennsylvania, Philadephia, PA, United States, Department of Pathology & Lab Medicine, University of(More)
BACKGROUND The need of an early and noninvasive diagnosis of AD requires the development of imagingbased techniques. As an alternative, the magnetic resonance image (MRI) relaxation time constant (T1ρ) was measured in brains of Alzheimer’s disease (AD), mild-cognitive impairment (MCI), and age-matched controls in order to determine whether T1ρ values(More)
Introduction: Balanced steady-state free precession (bSSFP) imaging offers a very high signal-to-noise ratio (SNR) and T2/T1-weighted image contrast useful for bright-blood MRI and fast imaging applications (1). The sequence requires a very short TR to reduce steady-state artifacts originating from the heterogeneity of the static magnetic field, but may(More)
Figure 2: Correlation of arthroscopic grade with T1ρ MRI. 14 arthroscopic observations of chondromalacia were made among 6 patients. Mean compartment T1ρ was abnormal in all cases of grade 3 and 4 chondromalacia, but mixed for grades 1 and 2. ROI analysis of the individual patients resolves the inconsistency among grades 1 and 2, for which heterogeneous and(More)
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