Erin L. Mazerolle

Learn More
PURPOSE Functional MRI (fMRI) techniques that can provide excellent blood oxygen level dependent contrast, rapid whole brain imaging, and minimal spatial distortion are in demand. This study explored whether fMRI sensitivity can be improved through the use of compressed sensing (CS) reconstruction of variable density spiral fMRI. METHODS Three different(More)
INTRODUCTION The idea of fMRI activation in white matter (WM) is controversial. Our recent work has used two different approaches to investigate whether there is evidence for WM fMRI. The first approach used words and faces to elicit interhemispheric transfer activation in the posterior corpus callosum (Sperry task). The second approach used checkerboard(More)
It is generally believed that activation in functional magnetic resonance imaging (fMRI) is restricted to gray matter. Despite this, a number of studies have reported white matter activation, particularly when the corpus callosum is targeted using interhemispheric transfer tasks. These findings suggest that fMRI signals may not be neatly confined to gray(More)
Recently, functional magnetic resonance imaging (fMRI) activation has been detected in white matter, despite the widely-held belief that fMRI activation is restricted to gray matter. The objective of the current study was to determine whether the regions of white matter fMRI activation were structurally connected to the functional network in gray matter. To(More)
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that allows for visualization of activated brain regions. Until recently, fMRI studies have focused on gray matter. There are two main reasons white matter fMRI remains controversial: (1) the blood oxygen level dependent (BOLD) fMRI signal depends on cerebral blood flow and volume,(More)
We have previously used functional magnetic resonance imaging to assess specific anterolateral temporal regions involved in object recognition, providing a novel technique for evaluating functional status in temporal lobe epilepsy (i.e., a site directed approach). However, a method that combines high temporal resolution with spatial mapping is needed to(More)
The blood oxygenation level-dependent (BOLD) phenomenon has profoundly revolutionized neuroscience, with applications ranging from normal brain development and aging, to brain disorders and diseases. While the BOLD effect represents an invaluable tool to map brain function, it does not measure neural activity directly; rather, it reflects changes in blood(More)
Introduction White matter fMRI is a controversial idea. To date, the majority of fMRI studies have focused on gray matter, largely for two reasons: 1) cerebral blood flow/volume is reduced in white matter relative to gray matter (e.g., [1, 2]); and 2) post-synaptic potentials are thought to be the primary source of the signal measured in fMRI (e.g., [3]).(More)
Functional magnetic resonance imaging (fMRI) activation in white matter is controversial. Given that many of the studies that report fMRI activation in white matter used high field MRI systems, we investigated the field strength dependence of sensitivity to white matter fMRI activation. In addition, we evaluated the temporal signal to noise ratio (tSNR) of(More)
Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation could be detected outside of the corpus callosum,(More)