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The androgen theory of autism proposes that autism spectrum conditions (ASC) are in part due to elevated fetal testosterone (FT) levels, which are positively correlated with a number of autistic traits and inversely correlated with social development and empathy. A medical questionnaire was completed by n=54 women with ASC, n=74 mothers of children with(More)
Autism spectrum conditions have been hypothesized to be an exaggeration of normal male low-empathizing and high-systemizing behaviors. We tested this hypothesis at the molecular level by performing comprehensive multi-analyte profiling of blood serum from adult subjects with Asperger's syndrome (AS) compared with controls. This led to identification of(More)
Molecular and behavioural evidence points to an association between sex-steroid hormones and autism spectrum conditions (ASC) and/or autistic traits. Prenatal androgen levels are associated with autistic traits, and several genes involved in steroidogenesis are associated with autism, Asperger Syndrome and/or autistic traits. Furthermore, higher rates of(More)
BACKGROUND The higher prevalence of Asperger Syndrome (AS) and other autism spectrum conditions in males has been known for many years. However, recent multiplex immunoassay profiling studies have shown that males and females with AS have distinct proteomic changes in serum. METHODS Here, we analysed sera from adults diagnosed with AS (males = 14, females(More)
Quantitative proteomic profiling is becoming a widely used approach in systems biology and biomarker discovery. There is a growing realization that quantitative studies require high numbers of unpooled samples for increased statistical power. Large-scale quantitative analyses require an added degree of stringency due to the lengthy study periods and(More)
BACKGROUND Substance use disorder (SUD) patients who engage in more continuing care have better outcomes, but information on practices associated with greater patient engagement and retention in continuing care remains elusive. OBJECTIVES The objectives of this study were to determine if staff's continuity of care practices predict patients' engagement in(More)
OBJECTIVE The purpose of this article is to describe the development and psychometric properties of parallel program-level and individual-level versions of the Continuity of Care Practices Survey (CCPS-P and CCPS-I), a measure that assesses four dimensions of continuity of care practices in substance use disorder (SUD) treatment programs. CCPS subscales(More)
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