Erin Harleton

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Addiction-associated behaviors such as drug craving and relapse are hypothesized to result from synaptic changes that persist long after withdrawal and are renormalized by drug reinstatement, although such chronic synaptic effects have not been identified. We report that exposure to the dopamine releaser methamphetamine for 10 days elicits a long-lasting(More)
Supplemental figure 1-Average release of FM1-43 over time from cortical terminals stimulated at 1 Hz, 10 Hz, and 20 Hz following repeated saline (A – C) or methamphetamine (D – F; 20 mg/kg/day, 10 days) on withdrawal day 10. Curves (red) demonstrate exponential fitting for first-order kinetics. Curves were fit with: A=Ao * EXP (-xt); x=ln(0.5) / t 1/2. For(More)
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