Erin Harleton

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Addiction-associated behaviors such as drug craving and relapse are hypothesized to result from synaptic changes that persist long after withdrawal and are renormalized by drug reinstatement, although such chronic synaptic effects have not been identified. We report that exposure to the dopamine releaser methamphetamine for 10 days elicits a long-lasting(More)
Supplemental figure 1-Average release of FM1-43 over time from cortical terminals stimulated at 1 Hz, 10 Hz, and 20 Hz following repeated saline (A – C) or methamphetamine (D – F; 20 mg/kg/day, 10 days) on withdrawal day 10. Curves (red) demonstrate exponential fitting for first-order kinetics. Curves were fit with: A=Ao * EXP (-xt); x=ln(0.5) / t 1/2. For(More)
The anticancer drug N,N,"N"-triethylenethiophosphoramide (tTEPA) inactivated CYP2B6 and CYP2B1 in the reconstituted system in a time-, concentration-, and NADPH-dependent manner indicative of mechanism-based inactivation. The KI value for the inactivation of CYP2B1 was 38 microM, the kinact was 0.3 min(-1), and the t1/2 value was 2.5 min. Spectral carbon(More)
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