Erin H Murphy

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The early appearance of monoamine systems in the developing mammalian CNS suggests that they play a role in neural development. We review data from two model systems that provide compelling new evidence of this role. In one model system-in utero exposure to cocaine-specific and robust alterations are seen in dopamine-rich areas of the cerebral cortex, such(More)
Receptive field characteristics of single cells in primary visual cortex of rabbit were studied. Seventy-two percent of cells were found to be orientation selective, and the remainder had concentric, uniform, movement selective or pure direction selective receptive fields. Single cells were also recorded from primary visual cortex of cat to permit a(More)
The effects of prenatal cocaine exposure on the development of the rabbit cerebral cortex were studied. Two cortical areas were compared: primary visual cortex (VC) and anterior cingulate cortex (ACC). ACC was selected because behavioral deficits observed in cocaine-exposed infants suggest the involvement of ACC. In addition, ACC receives dense dopaminergic(More)
1. The mechanical properties of motor units of the cat superior oblique muscle and axonal conduction velocities of trochlear motoneurons have been studied at several postoperative times after intracranial axotomy of the trochlear nerve. 2. Whole muscle twitch forces were generally within the normal range by approximately 4 mo postoperative, indicating that(More)
The innervation of extraocular muscles in the rabbit was studied by using the methods of horseradish peroxidase (HRP) histochemistry, gross dissection, and quantitative morphology. Subdivisions of the oculomotor complex that innervate the superior rectus, inferior rectus, medial rectus, and inferior oblique and levator palpebrae are described, and our(More)
The rabbit has been used to model the potential effects of in utero exposure to cocaine on fetal and postnatal development. Special advantages of this animal model include the fact that cocaine can be easily administered intravenously, thus mimicking crack cocaine use by pregnant women. Results indicate that at the dosage used (8 mg/kg of body weight, given(More)
OBJECTIVE To evaluate percutaneous mechanical thrombectomy for deep venous thrombosis (DVT). DESIGN A retrospective analysis. SETTING Tertiary academic medical center. PATIENTS Thirty patients with DVT who underwent percutaneous mechanical thrombectomy. INTERVENTIONS Percutaneous mechanical thrombectomy of upper or lower extremity DVT. MAIN(More)
To determine if functional alterations in the superior colliculus might account for recovery of visual behaviors following visual cortex removal in infant cats, the receptive field characteristics of single units in the superior colliculus of cats whose visual cortex was removed within the first week of life were compared with those of cats which sustained(More)