Erin C. Macaulay

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The human placenta is hypomethylated compared to somatic tissues. However, the degree and specificity of placental hypomethylation across the genome is unclear. We assessed genome-wide methylation of the human placenta and compared it to that of the neutrophil, a representative homogeneous somatic cell. We observed global hypomethylation in placenta(More)
Pre-eclampsia is a dangerous placental condition that can lead to premature labour, seizures and death of mother and infant. It is the most common pregnancy complication in the developed world, occurring in 5--10% of pregnancies (15--18% in developing countries) [1--3]. Unfortunately, diagnosis of pre-eclampsia is difficult as the clinical symptoms(More)
In the human placenta, DNA hypomethylation permits the expression of retrotransposon-derived genes that are normally silenced by methylation in somatic tissues. We previously identified hypomethylation of a retrotransposon-derived transcript of the voltage-gated potassium channel gene KCNH5 that is expressed only in human placenta. However, an RNA sequence(More)
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