Erin C. Macaulay

Learn More
The human placenta is hypomethylated compared to somatic tissues. However, the degree and specificity of placental hypomethylation across the genome is unclear. We assessed genome-wide methylation of the human placenta and compared it to that of the neutrophil, a representative homogeneous somatic cell. We observed global hypomethylation in placenta(More)
Pre-eclampsia is a dangerous placental condition that can lead to premature labour, seizures and death of mother and infant. It is the most common pregnancy complication in the developed world, occurring in 5--10% of pregnancies (15--18% in developing countries) [1--3]. Unfortunately, diagnosis of pre-eclampsia is difficult as the clinical symptoms(More)
In the human placenta, DNA hypomethylation permits the expression of retrotransposon-derived genes that are normally silenced by methylation in somatic tissues. We previously identified hypomethylation of a retrotransposon-derived transcript of the voltage-gated potassium channel gene KCNH5 that is expressed only in human placenta. However, an RNA sequence(More)
Obesity and its related non-communicable diseases (NCDs), such as type 2 diabetes, heart disease and cancer, impose huge burdens on society, particularly the healthcare system. Until recently, public health and policy were primarily focused on secondary prevention and treatment of NCDs. However, epidemiological and experimental evidence indicates that(More)
  • 1