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The translation of basic research into improved therapies for breast cancer patients requires relevant preclinical models that incorporate spontaneous metastasis. We have completed a functional and molecular characterisation of a new isogenic C57BL/6 mouse model of breast cancer metastasis, comparing and contrasting it with the established BALB/c 4T1 model.(More)
Metastatic progression is the major cause of breast cancer-related mortality. By examining multiple syngeneic preclinical breast cancer models in mice lacking a functional type-I interferon receptor (Ifnar1(-/-) mice), we show that host-derived type-I interferon (IFN) signaling is a critical determinant of metastatic spread that is independent of primary(More)
ALASKA DIVISION Gunter E. Weller Irma Duncan President Executive Secretary PHYSICS (B) CHEMISTRI Edwin M. McMillan Thomas E. RoIf M. Sinclair Leo Schube SOCIAL AND ECONOMIC SCIENCES (K) Robert K. Marton Harvey Sapolsky EDUCATION (Q) DENTISTR Gordon Swanson Martin C Phillip R. Fordyce Sholom F PACIFIC DIVISION John 0. Isaacs Robert T. Orr President(More)
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