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The brain encounters input varying with many different time courses. Given such temporal variability, it would seem practical for adaptation to operate at multiple timescales. Indeed, to account for peculiar effects such as spacing, savings, and spontaneous recovery, many recent models of learning and adaptation have postulated multiple mechanisms operating(More)
Acute mountain sickness (AMS) is a common condition occurring within hours of rapid exposure to high altitude. Despite its frequent occurrence, the pathophysiological mechanisms that underlie the condition remain poorly understood. We investigated the role of cerebral oxygen metabolism (CMR(O(2))) in AMS. The purpose of this study was to test 1) if(More)
Objects are critical functional units for many aspects of visual perception and recognition. Many psychophysical experiments support the concept of an "object file" consisting of characteristics attributed to a single object on the basis of successive views of it, but there has been little evidence that object identity influences apparent brightness and(More)
Ventilation and cerebral blood flow (CBF) are both sensitive to hypoxia and hypercapnia. To compare chemosensitivity in these two systems, we made simultaneous measurements of ventilatory and cerebrovascular responses to hypoxia and hypercapnia in 35 normal human subjects before and after acclimatization to hypoxia. Ventilation and CBF were measured during(More)
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