Eriko Oshima

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Glucosylceramide synthase (GlcT-1) catalyzes the formation of glucosylceramide (GlcCer), the core structure of major glycosphingolipids (GSLs), from ceramide and UDP-glucose. Ceramide and its metabolites, such as sphingosine-1-phosphate, are now known to be important mediators of apoptosis and cell survival. Recently, we have shown that GlcT-1 functions to(More)
Although GPRC5B and GPRC5C are categorized into the G protein-coupled receptor family C, including glutamate receptors, GABA receptors, and taste receptors, their physiological functions remain unknown. Since both receptors are expressed in the brain and evolutionarily conserved from fly to human, it is conceivable that they have significant biological(More)
The effect of ketamine on excitatory synaptic transmission was examined in vitro in slices of guinea-pig hippocampus. Ketamine (100-500 microM) depressed the amplitude of the field excitatory post-synaptic potential (e.p.s.p.) and the population spike evoked in the dentate gyrus by stimulation of the perforant path. It did not affect the coupling between(More)
Glycosphingolipids and cholesterol are principal components of plasmamembrane microdomains, i.e. lipid rafts. Recent studies revealed the possible presence of a variety of microdomains that distinctly differ in terms of their molecular composition and functions. To understand their precise structures and functions, we produced monoclonal antibodies (MAbs)(More)
Glycosphingolipids (GSLs) occur in all mammalian plasma membranes. They are most abundant in neuronal cells and have essential roles in brain development. Glucosylceramide (GlcCer) synthase, which is encoded by the Ugcg gene, is the key enzyme driving the synthesis of most neuronal GSLs. Experiments using conditional Nestin-Cre Ugcg knockout mice have shown(More)
w The human wrnea is a densely innervated struchxe. However, data on nerve fiber (NF) distribution in tbe human cornea are scarce possibly due to fast post mortem degeneration. Therefore, moat descriptions on comeal innervation are based on studies in rats and rabbits. Tbe present study is focussed on the ulaastruaure of NF’s in the central and peripheral(More)
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