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Bovine papillomavirus type 12 (BPV-12, putative type BAA1) was detected in epithelial papilloma located on the tongue of an infected cow. Then, the whole genome was sequenced, and phylogenetic analysis illustrated that it should be classified as a member of the genus Xipapillomavirus. The viral genome is 7197 base pairs in length and contains five early(More)
PURPOSE To investigate independent risk factors related to the progression of non-proliferative diabetic retinopathy (NPDR) for Japanese Type 2 diabetic patients. METHODS One hundred and six patients with NPDR were followed up for 2 years. Diabetic retinopathy (DR) was determined by colour fundus photography. Multivariate logistic regression analysis was(More)
PURPOSE To identify the reasons why diabetic patients do not undergo periodic examination. DESIGN Cohort study. METHODS A questionnaire survey of 1,333 Japanese type 2 diabetic patients was conducted at Tokyo Women's Medical University. Performance of ocular examinations was investigated over 5 years and the reasons for not undergoing examination were(More)
PURPOSE To investigate whether angiotensin II (AII) or vascular endothelial growth factor (VEGF) is related to diabetic macular edema (DME) in patients with and without posterior vitreous detachment (PVD). DESIGN A case-control study. METHODS Vitreous fluid samples were obtained at vitreoretinal surgery from 28 eyes of 28 DME patients without PVD, 8(More)
PURPOSE To ascertain whether the aqueous humor levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and protein can predict the postoperative exacerbation of macular edema in patients with nonproliferative diabetic retinopathy (NPDR) after phacoemulsification surgery for cataract. SETTING Department of Ophthalmology, Diabetes Center,(More)
PURPOSE To find a predictor in the pathogenesis of macular edema, we investigated ocular and systemic risk factors. METHODS One hundred and fifty-nine patients with mild diabetic retinopathy who showed one or more soft exudates were recruited. We selected the possible predictors on the basis of relevant factors, including concentration of vascular(More)
PURPOSE To investigate the relationship between human leukocyte antigen (HLA) status and proliferative diabetic retinopathy (PDR) to assess the genetic basis of PDR in younger type 1 diabetic patients. DESIGN Retrospective, nonrandomized, comparative trial. METHOD Patients who were diagnosed with type 1 diabetes under 30 years of age (range, 13-28) and(More)
OBJECTIVE To investigate the relationship of HLA status and autoantibodies to glutamic acid decarboxylase (GAD) in proliferative diabetic retinopathy (PDR) to assess the role of autoimmunity and genetic markers in retinopathy. DESIGN Retrospective, nonrandomized, comparative study. PARTICIPANTS Patients who had suffered from type 1 diabetes for >10(More)
PURPOSE To evaluate the blood flow velocity in the ophthalmic artery using color Doppler imaging in two patients who had diabetic retinopathy with amaurosis fugax caused by orthostatic hypotension. DESIGN Interventional case reports. METHODS A 40-year-old woman (Case 1) and a 65-year-old man (Case 2) had diabetic retinopathy and amaurosis fugax caused(More)
PURPOSE To investigate the awareness and understanding of ophthalmologic complications by diabetic patients and assess the problems. SUBJECTS AND METHODS In August 1999, a questionnaire survey was done of 3,613 diabetic outpatients attending the Department of Internal Medicine at Tokyo Women's Medical University Diabetes Center. RESULTS Patients who(More)