Erika M. Cook

Rob N de Jong1
Paul WHI Parren1
Marleen Voorhorst1
Patrick HC van Berkel1
1Rob N de Jong
1Paul WHI Parren
1Marleen Voorhorst
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  • Ewald TJ van den Bremer, Frank J Beurskens, Marleen Voorhorst, Patrick J Engelberts, Rob N de Jong, Burt G van der Boom +5 others
  • 2015
Human IgG is produced with C-terminal lysines that are cleaved off in circulation. The function of this modification was unknown and generally thought not to affect antibody function. We recently reported that efficient C1q binding and complement-dependent cytotoxicity (CDC) requires IgG hexamerization at the cell surface. Here we demonstrate that(More)
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