Learn More
The mitochondrial uniporter is a highly selective calcium channel in the organelle's inner membrane. Its molecular components include the EF-hand-containing calcium-binding proteins mitochondrial calcium uptake 1 (MICU1) and MICU2 and the pore-forming subunit mitochondrial calcium uniporter (MCU). We sought to achieve a full molecular characterization of(More)
BACKGROUND The Tic complex (Translocon at the inner envelope membrane of chloroplasts) mediates the translocation of nuclear encoded chloroplast proteins across the inner envelope membrane. Tic110 forms one prominent protein translocation channel. Additionally, Tic20, another subunit of the complex, was proposed to form a protein import channel - either(More)
Most chloroplast proteins are encoded for in the nucleus and have to be transported into the organelle after translation in the cytoplasm. The TOC and TIC machineries (Translocon at the Outer/Inner envelope membrane of Chloroplasts) mediate the import of these proteins across the chloroplast membranes. The major aim of this work was to characterize two TIC(More)
  • 1