Erika Hirota

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Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a(More)
1. INTRODUCTION Lipocalin-type prostaglandin (PG) D synthase (L-PGDS, EC 5.3.99.2) catalyzes the isomerization of PGH 2 , a common precursor of various prostanoids, to produce PGD 2 and is involved in the regulation of pain 1 and of nonrapid eye movement sleep in the central nervous system, 2 the sex differentiation of male genitals, 3 the cardiovascular(More)
Human haematopoietic prostaglandin D synthase (H-PGDS; EC 5.3.99.2) produces prostaglandin D(2), an allergic and inflammatory mediator, in mast cells and Th2 cells. H-PGDS has been crystallized with novel inhibitors with half-maximal inhibitory concentrations (IC(50)) in the low nanomolar range by the counter-diffusion method onboard the Russian Service(More)
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