Erika Hirota

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Human hematopoietic prostaglandin synthase, one of the better therapeutic target enzymes for allergy and inflammation, was crystallized with 22 inhibitors and in three inhibitor-free conditions in microgravity. Most of the space-grown crystals showed better X-ray diffraction patterns than the terrestrially grown ones, indicating the advantage of a(More)
Human haematopoietic prostaglandin D synthase (H-PGDS; EC 5.3.99.2) produces prostaglandin D(2), an allergic and inflammatory mediator, in mast cells and Th2 cells. H-PGDS has been crystallized with novel inhibitors with half-maximal inhibitory concentrations (IC(50)) in the low nanomolar range by the counter-diffusion method onboard the Russian Service(More)
Lipocalin-type prostaglandin (PG) D synthase (L-PGDS, EC 5.3.99.2) catalyzes the isomerization of PGH2, a common precursor of various prostanoids, to produce PGD2 and is involved in the regulation of pain and of nonrapid eye movement sleep in the central nervous system, the sex differentiation of male genitals, the cardiovascular function in the heart and(More)
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