Erik van Lunteren

Learn More
The role of upper airway muscle contractile dysfunction in the pathophysiology of sleep apnea is not clear. The conventional understanding of this disorder is that anatomical narrowing of the upper airway combined with inadequate activation of upper airway dilator muscles leads to airway closure and obstructive apneas.1 The possibility of upper airway(More)
K channels regulate action potential duration and thereby force of skeletal muscles. Diaphragm differs from limb muscles in the dependence of contraction on extracellular Ca. We hypothesized that diaphragm also differs from limb muscles in the regulation of contraction by membranous K conductances. This was tested in vitro by assessing changes in isometric(More)
Van Lunteren, Erik, Michelle Moyer, and Augusto Torres. ATP-sensitive K1 channel blocker glibenclamide and diaphragm fatigue during normoxia and hypoxia. J. Appl. Physiol. 85(2): 601–608, 1998.—The role of ATP-sensitive K1 channels in skeletal muscle contractile performance is controversial: blockers of these channels have been found to not alter,(More)
Background: Diabetes profoundly affects gene expression in organs such as heart, skeletal muscle, kidney and liver, with areas of perturbation including carbohydrate and lipid metabolism, oxidative stress, and protein ubiquitination. Type 1 diabetes impairs lung function, but whether gene expression alterations in the lung parallel those of other tissue(More)
Van Lunteren, Erik, and Michelle Moyer. Effects of DAP on diaphragm force and fatigue, including fatigue due to neurotransmission failure. J. Appl. Physiol. 81(5): 2214– 2220, 1996.—Among the aminopyridines, 3,4-diaminopyridine (DAP) is a more effective K1 channel blocker than is 4-aminopyridine (4-AP), and, furthermore, DAP enhances neuromuscular(More)
Migration of myoblasts is an important component of the reparative response to muscle injury, and furthermore may be a key determinant of the success of myoblast transplantation for the treatment of genetic muscle diseases. The present study examined the hypothesis that K+ channels modulate myoblast migration. The migration of cultured L-6 myoblasts was(More)
Stimulation of the tonic muscle receptor organs inProcambarus clarkii results in reflex activation of the superficial extensors. This pathway is inhibited by activity in the lateral giant fibers and both medial giants. A labile synapse in the same pathway works synergistically with the giant fiber-mediated inhibition to prevent maladaptive activation of the(More)
  • 1