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  • Erik Wambre, Jonathan H DeLong, Eddie A James, Rebecca E Lafond, David Robinson, William W Kwok
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2012 (First Published: 1 February 2012)
  • BACKGROUND The main obstacle to elucidating the role of CD4(+) T cells in allergen-specific immunotherapy (SIT) has been the absence of an adequately sensitive approach to directly characterize rareContinue Reading
  • Erik Wambre, Veronique Bajzik, +13 authors William W Kwok
  • Biology, Medicine
  • Science Translational Medicine
  • 2017 (First Published: 2 August 2017)
  • Allergen-specific type 2 helper T (TH2) cells play a central role in initiating and orchestrating the allergic and asthmatic inflammatory response pathways. One major factor limiting the use of suchContinue Reading
  • Jonathan H DeLong, Kelly Hetherington Simpson, Erik Wambre, Eddie A James, David Robinson, William W Kwok
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2011 (First Published: 1 May 2011)
  • BACKGROUND Effective immunotherapy for peanut allergy is hampered by a lack of understanding of peanut-reactive CD4(+) T cells. OBJECTIVE To identify, characterize, and track Ara h 1-reactive cellsContinue Reading
  • Erik Wambre, Jonathan H DeLong, +7 authors William.W. Kwok
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 2013 (First Published: 1 March 2014)
  • BACKGROUND Understanding the mechanisms by which the immune system induces and controls allergic inflammation at the T-cell epitope level is critical for the design of new allergy vaccine strategies.Continue Reading
  • Laurence van Overtvelt, Erik Wambre, +8 authors Philippe Moingeon
  • Biology, Medicine
  • Journal of immunology
  • 2008 (First Published: 1 April 2008)
  • In this study, we used HLA-DRB1*0101, DRB1*0401, and DRB1*1501 peptide tetramers combined with cytokine surface capture assays to characterize CD4(+) T cell responses against the immunodominant TContinue Reading
  • Mélodie Bonvalet, Hélène Moussu, +8 authors Philippe Moingeon
  • Medicine
  • Clinical and experimental allergy : journal of…
  • 2012 (First Published: 1 December 2012)
  • BACKGROUND Surrogate biomarkers of efficacy are needed in support of allergen-specific immunotherapy. OBJECTIVE The aim of this study was to relate changes in peripheral CD4(+) T cell responses toContinue Reading