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BACKGROUND Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization. METHODS The spatial distribution of nitrogen oxides from traffic (traffic-NOx) and inhalable particulate matter from traffic (traffic-PM10) in the(More)
BACKGROUND The role of exposure to air pollution in the development of allergic sensitization remains unclear. OBJECTIVE We sought to assess the development of sensitization until school age related to longitudinal exposure to air pollution from road traffic. METHODS More than 2500 children in the birth cohort BAMSE (Children, Allergy, Milieu,(More)
BACKGROUND Air pollutants may induce airway inflammation and sensitization due to generation of reactive oxygen species. The genetic background to these mechanisms could be important effect modifiers. OBJECTIVE Our goal was to assess interactions between exposure to air pollution and single nucleotide polymorphisms (SNPs) in the beta2-adrenergic receptor(More)
OBJECTIVE To assess the effects of living in agreement with allergy preventive guidelines on wheezing and asthma at 2 years of age. DESIGN Prospective birth cohort study (BAMSE). Questionnaires on heredity and environmental factors were answered when the child was 2 months, and detailed questionnaires on symptoms at 1 and 2 years of age. PARTICIPANTS(More)
Cockroaches produce potent allergens that are an important cause of asthma. The two principal domiciliary cockroach species, Blattella germanica and Periplaneta americana, secrete major allergens, Bla g 1 and Per a 1. Here, we report the molecular cloning of three Bla g 1 cDNA clones, which showed 70% amino acid sequence identity with Per a 1. Plaque(More)
Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment. MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for(More)
BACKGROUND Neonatal screening for metabolic diseases, involving samples stored on filter paper (Guthrie spots), provides a potential resource for genetic epidemiological studies. OBJECTIVE To develop a method to make these dried blood spots available for large scale genetic epidemiology. METHODS DNA from untraceable Guthrie spots was extracted using a(More)
BACKGROUND Boys have been reported to be more susceptible to childhood wheezing, whereas girls are more susceptible later in life. This difference might be related to both genetic and environmental factors. OBJECTIVE To investigate the influence of male sex and parental allergic disease on the development of childhood wheezing. METHODS Infants (n=4089)(More)
A sthma and wheezing are characterised by airway inflammation and reversible airflow obstruction, and seem to have multiple phenotypes that may differ on the basis of age of onset. 1 Boys are more prone to develop wheezing and asthma in the early years, whereas girls are more susceptible later in life. 2–4 Whether this difference is due to genetic,(More)
BACKGROUND Understanding the genetic basis of airflow obstruction and smoking behaviour is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). We used UK Biobank data to study the genetic causes of smoking behaviour and lung health. METHODS We sampled individuals of European ancestry from UK Biobank, from the middle and(More)