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FUS, EWSR1 and TAF15, constituting the FET protein family, are abundant, highly conserved RNA-binding proteins with important roles in oncogenesis and neuronal disease, yet their RNA targets and recognition elements are unknown. Using PAR-CLIP, we defined global RNA targets for all human FET proteins and two ALS-causing human FUS mutants. FET members showed(More)
The vascular endothelial growth factors (VEGFs) are major angiogenic regulators and are involved in several aspects of endothelial cell physiology. However, the detailed role of VEGF-B in blood vessel function has remained unclear. Here we show that VEGF-B has an unexpected role in endothelial targeting of lipids to peripheral tissues. Dietary lipids(More)
A test solution for a complex system requires the design of a test access mechanism (TAM), which is used for the test data transportation, and a test schedule of the test data transportation on the designed TAM. An extensive TAM will lead to lower test-application time at the expense of higher routing costs, compared to a simple TAM with low routing cost(More)
1 In this paper we address the test scheduling problem for system-on-chip designs. Different from previous approaches where it is assumed that all tests will be performed until completion, we consider the cases where the test process will be terminated as soon as a defect is detected. This is common practice in production test of chips. The proposed(More)
Modern chips may contain a large number of embedded test, debugging, configuration, and monitoring features, called instruments. An instrument and its instrument access procedures may be pre-developed and reused, and each instrument—in different chips and through the lifetime of a chip—may be accessed in different ways, which requires retargeting. To(More)
In this paper we propose a framework for the testing of system-on-chip (SOC), which includes a set of design algorithms to deal with test scheduling, test access mechanism design, test sets selection, test parallelization, and test resource placement. The approach minimizes the test application time and the cost of the test access mechanism while(More)
We propose an integrated framework for the design of SOC test solutions, which includes a set of algorithms for early design space exploration as well as extensive optimization for the final solution. The framework deals with test scheduling, test access mechanism design, test sets selection, and test resource placement. Our approach minimizes the test(More)
An integrated technique for test scheduling and scan-chain division under power constraints is proposed in this paper. We demonstrate that optimal test time can be achieved for systems tested by an arbitrary number of tests per core using scan-chain division and we define an algorithm for it. The design of wrappers to allow different lengths of scan-chains(More)
Viruses cause 10-15% of all human cancers. Massively parallel sequencing has recently proved effective for uncovering novel viruses and virus-tumour associations, but this approach has not yet been applied to comprehensive patient cohorts. Here we screen a diverse landscape of human cancer, encompassing 4,433 tumours and 19 cancer types, for known and novel(More)
OBJECTIVE Our previous studies suggest that the SNARE protein synaptosomal-associated protein of 23 kDa (SNAP23) is involved in the link between increased lipid levels and insulin resistance in cardiomyocytes. The objective was to determine whether SNAP23 may also be involved in the known association between lipid accumulation in skeletal muscle and insulin(More)