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  • Alain C. Mita, Chris H M Takimoto, +11 authors Patricia Lorusso
  • Medicine
  • Clinical cancer research : an official journal of…
  • 1 June 2010
  • PURPOSE To evaluate the safety, pharmacokinetics, and antitumor activity of AMG 386, an investigational selective angiopoietin 1/2-neutralizing peptibody, in combination with FOLFOX-4 (F),Continue Reading
  • Desmond Padhi, Celestia S. Higano, Neal D Shore, Paul R. Sieber, Erik J. Rasmussen, Matthew R Smith
  • Medicine
  • The Journal of clinical endocrinology and…
  • 1 October 2014
  • CONTEXT Myostatin is a negative regulator of muscle growth. Androgen deprivation (ADT) is associated with muscle loss and increased body fat, and currently available therapies have limited efficacyContinue Reading
  • William Stohl, Joan T. Merrill, +14 authors Debra Jeske Zack
  • Medicine
  • Arthritis Research & Therapy
  • 1 December 2015
  • IntroductionBlisibimod is a potent B cell-activating factor (BAFF) antagonist that binds to both cell membrane-expressed and soluble BAFF. The goal of these first-in-human studies was to characterizeContinue Reading