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A young cat had signs of tetraparesis that progressed to tetraplegia within a few weeks. Clinically, there was lower motor neuron disease with areflexia and muscle atrophy in all limbs. Degeneration of the motor neurons in the spinal cord was seen on histological examination. Ultrastructurally, the degeneration of nerve cells was characterized by abnormal(More)
Two young zebra siblings from consecutive pregnancies suffered from neurological disease, characterized by ventral deviation of the neck and tetraparesis which progressed to tetraplegia within a few weeks. On histological examination widespread neuronal degeneration was observed in the ventral horns of the spinal cord and in the lower brain stem.(More)
One of 8 highly inbred Dalmatian pups was born with generalized body tremors, which interfered with the pup's ability to suckle, walk, and maintain sternal recumbency. The pup's head, neck, and limbs oscillated rhythmically when it attempted to perform any motor function. The pup was euthanatized at 8 weeks of age, after it became apparent that the disorder(More)
Proximal and distal skeletal muscles from pectoral and pelvic limbs were histochemically examined in 18 neuromuscular disease-free dogs. On the basis of the human system of classification and nomenclature and results of standard adenosine triphosphatase (ATPase) and glycine-formaldehyde preincubation procedures, the fiber types identified in immature and(More)
Two dogs each had a fibrous tumor of the central nervous system. One tumor involved the spinal cord and ventral nerve root, and the other involved the midbrain and posterior brain stem. Both tumors had spindle-shaped cells arranged in rhythmic patterns. There was perivascular tumor cell infiltration in the adjacent parenchyma. The tumor cells strongly(More)
In 10 of 16 domestic cats with spontaneous non-suppurative encephalomyelitis, lesions were multifocal but relatively few and were considered nonspecific as to cause, although viral agents could not be excluded. Six cats had polioencephalomyelitis or polioencephalitis suggestive of viral infection. The clinical and morphological features are compared with(More)
Levamisole was given orally to 3 groups of dogs, totaling 56 animals. Drug administration period varied from 1 to 120 days. All animals were killed and the central nervous system was examined histologically. Lesions were found in 44 of 56 dogs. These consisted of disseminated perivascular cuffing with mononuclear cells throughout the brain and meninges. The(More)
Cold hemagglutinin disease, a form of autoimmune hemolytic anemia caused by cold-acting erythrocyte autoantibodies, was diagnosed in a dog. Cold-acting antibodies differ from warm-acting antibodies in several ways, including temperature-dependent reactivity below 32 C. The autoantibody in this case (immunoglobulin M) was in the serum in higher than normal(More)