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Thyroid stimulating hormone (TSH)-associated follicular hypertrophy and hyperplasia as a mechanism of thyroid carcinogenesis in mice and rats G. A mechanistic relationship between thyroid follicular cell tumours and hepatocellular neoplasms in rodents Human renal-cell carcinoma—epidemiological and mechanistic aspects A. Mellemgaard Human renal(More)
This review provides a framework contributing to the risk assessment of acrylamide in food. It is based on the outcome of the ILSI Europe FOSIE process, a risk assessment framework for chemicals in foods and adds to the overall framework by focusing especially on exposure assessment and internal dose assessment of acrylamide in food. Since the finding that(More)
Daily mean intakes of acrylamide present in foods and coffee in a limited Norwegian exposure assessment study have been estimated to be 0.49 and 0.46 microg per kg body weight in males and females, respectively. Testicular mesotheliomas and mammary gland adenomas have consistently been found in 2-year drinking water rat cancer studies with acrylamide.(More)
Many wildlife species may be exposed to biologically active concentrations of endocrine-disrupting chemicals. There is strong evidence obtained from laboratory studies showing the potential of several environmental chemicals to cause endocrine disruption at environmentally realistic exposure levels. In wildlife populations, associations have been reported(More)
Occupational exposure to hexabromocyclododecane (HBCD) among workers at an industrial plant producing expandable polystyrene (PS) added HBCD as flame retardant has been assessed in the present study. Airborne dust samples were collected near the breathing zone of 10 male workers during three 8-h work shifts. The HBCD concentrations in the airborne dust(More)
1 UCSD School of Medicine, San Diego, California, USA; 2 Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; 3 Cancer Council of Victoria, Melbourne, Victoria, Australia; 4 University of Minnesota Cancer Center, Minneapolis, Minnesota, USA; 5 Department of Environmental and Occupational Cancer, Institute of Cancer(More)
A.G. Renwick, S.M. Barlow, I. Hertz-Picciotto, A.R. Boobis, E. Dybing, L. Edler, G. Eisenbrand, J.B. Greig, J. Kleiner*, J. Lambe, D.J.G. Müller, M.R. Smith, A. Tritscher, S. Tuijtelaars, P.A. van den Brandt, R. Walker, R. Kroesp,y University of Southampton, Clinical Pharmacology Group, School of Medicine, Biomedical Sciences Building, Bassett Crescent(More)
Chlorination of drinking water that contains organic compounds leads to the formation of by-products, some of which have been shown to have mutagenic or carcinogenic effects. As yet, too little is known about the possible teratogenic effects on the human fetus. We linked the Norwegian waterwork registry, containing 1994 data on chlorination practice and(More)
Identifying the ambient particulate matter (PM) fractions or constituents, critically involved in eliciting adverse health effects, is crucial to the implementation of more cost-efficient abatement strategies to improve air quality. This review focuses on the importance of different particle properties for PM-induced effects, and whether there is(More)
This report provides guidance for using the dose-descriptor T25 from animal studies as a basis for quantitative risk characterisation of non-threshold carcinogens. T25 is presently used within the European Union for setting specific concentration limits for carcinogens in relation to labelling of preparations (formulations). The T25 is defined as the(More)