Erik Andries

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To determine whether gene expression profiling could improve risk classification and outcome prediction in older acute myeloid leukemia (AML) patients, expression profiles were obtained in pretreatment leukemic samples from 170 patients whose median age was 65 years. Unsupervised clustering methods were used to classify patients into 6 cluster groups(More)
BACKGROUND In the differential diagnosis of a tachycardia with a wide QRS complex (greater than or equal to 0.12 second) diagnostic mistakes are frequent. Therefore, we investigated the reasons for failure of presently available criteria, and we identified new, simpler criteria and incorporated them in a stepwise approach that provides better sensitivity(More)
Two hundred thirty-five patients underwent RF catheter ablation of AV conduction for symptomatic drug refractory AF (84%), atrial flutter (9%), and atrial tachycardia (7%). In the first 100 patients, postablation pacing was not prospectively set at any specific rate and was always < or = 70 beats/min. In the next 135 patients, postablation pacing was(More)
BACKGROUND Many criteria have been published to localize accessory pathways from the 12-lead ECG during sinus rhythm. This study analyzed whether the localization of an accessory pathway could be predicted by using the polarity of the QRS complex during sinus rhythm on the surface ECG, instead of the delta wave polarity as used in many reports. METHODS(More)
The 12-lead surface electrocardiogram is a simple and useful tool for the differential diagnosis of regular wide QRS complex tachycardia. However, criteria do not as yet exist to discriminate between ventricular tachycardia and supraventricular tachycardia with anterograde conduction over an accessory pathway (preexcited tachycardia). Therefore, we designed(More)
The incidence and consequences of inappropriate sinus tachycardia following modification of the AV nodal area with radiofrequency energy were prospectively studied in a consecutive series of 118 patients. Twelve (10%) patients developed this complication, which persisted less than 1 week in all but three patients. Inappropriate sinus tachycardia was only(More)
Most multivariate calibration methods require selection of tuning parameters, such as partial least squares (PLS) or the Tikhonov regularization variant ridge regression (RR). Tuning parameter values determine the direction and magnitude of respective model vectors thereby setting the resultant predication abilities of the model vectors. Simultaneously,(More)