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BACKGROUND Atrial fibrillation occurs frequently in patients with congestive heart failure and commonly results in clinical deterioration and hospitalization. Sinus rhythm may be maintained with antiarrhythmic drugs, but some of these drugs increase the risk of death. METHODS We studied 1518 patients with symptomatic congestive heart failure and severe(More)
Frequency domain analysis of heart rate variability (HRV) has been proposed as a semiquantitative method for assessing activities in the autonomic nervous system. We examined whether absolute powers, normalized powers, and the low frequency-to-high frequency ratio (LF/HF) derived from the HRV power spectrum could detect shifts in autonomic balance in a(More)
BACKGROUND Arrhythmias cause much morbidity and mortality after myocardial infarction, but in previous trials, antiarrhythmic drug therapy has not been convincingly effective. Dofetilide, a new class III agent, was investigated for effects on all-cause mortality and morbidity in patients with left-ventricular dysfunction after myocardial infarction. (More)
In a ten-year prospective study of a population of men and women aged exactly 70 at entry and otherwise selected only according to geography, the predictive values of serum cholesterol and serum triglycerides were evaluated concerning total mortality and cardiovascular disease (CVD) and cancer manifestations in the eighth decade. Both high and low(More)
Coenzyme Q10 (ubiquinone) the essential mitochondrial redox-component and endogenous antioxidant, packaged into the LDL + VLDL fractions of cholesterol, has been suggested as an important anti-risk factor for the development of atherosclerosis as explained by the oxidative theory. Forty-five hypercholesterolemic patients were randomized in a double-blind(More)
INTRODUCTION The term chaos is used to describe erratic or apparently random time-dependent behavior in deterministic systems. It has been suggested that the variability observed in the normal heart rate may be due to chaos, but this question has not been settled. METHODS AND RESULTS Heart rate variability was assessed by recordings of consecutive RR(More)
BACKGROUND Measures of QT dynamics express repolarization abnormalities that carry prognostic information, but the reproducibility of beat-to-beat QT dynamics has never been established. The QT interval is prolonged at night, but how the circadian rhythm and heart rate influence the dynamic QT measurements is still unsettled. The aims of the present study(More)
OBJECTIVES The purpose of the study was to investigate the short- and long-term variations in the non-linear dynamics of heart rate variability, and to determine the relationships between conventional time and frequency domain methods and the newer non-linear methods of characterizing heart rate variability. METHODS Twelve healthy subjects were(More)
INTRODUCTION Inherited long QT syndrome (LQTS) recently has been associated with mutations in genes coding for potassium (KVLQT1, KCNE1, and HERG) or sodium (SCN5A) ion channels involved in regulating either sodium inward or potassium outward currents of heart cells, resulting in prolongation of the repolarization period. We describe a new mutation, a -1(More)
The serum concentrations of 1,25-dihydroxyvitamin D (1,25-(OH)2D) were measured in 194 healthy subjects aged 15-90 years. The mean level was 32.8 +/- 12.5 pg/ml (SD) without age-dependent changes. The mean serum concentration was reduced (26.9 +/- 13.6 pg/ml) in 55 patients with postmenopausal osteopenia compared to 62 non-osteopenic age-matched controls(More)