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ETHNOPHARMACOLOGICAL RELEVANCE Premna odorata Blanco (Lamiaceae) is a medicinal plant traditionally used in Albay Province, in southeastern Luzon, Philippines to treat tuberculosis. This study aimed… (More)
Aldehyde oxidase (AOX) is a cytosolic enzyme responsible for the metabolism of some drugs and drug candidates. AOX catalyzes the oxidative hydroxylation of substrates including several aliphatic and… (More)
The DeFIT it! Program utilizes the use of a diet diary and heath teaching through the use of SMS texting. It was designed for the respondents to acquire knowledge on proper diet and physical … (More)
Bioassay-guided chromatographic purification of the crude -methanolic extract of the Philippine medicinal plant Uvaria rufa carteri resulted in the isolation and identification of a mixture 1:1 the… (More)
Although aldehyde oxidase (AO) is an important hepatic drug-metabolizing enzyme, it remains understudied and is consequently often overlooked in preclinical studies, an oversight that has resulted in… (More)
We investigate the mechanism of time-dependent inhibition (TDI) of human cytochrome P450 2D6 (CYP2D6) by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), one of the most widespread recreational… (More)
Aldehyde oxidase (AO) is a cytosolic enzyme responsible for the metabolism of some drugs and drug candidates. AO catalyzes the oxidative hydroxylation of substrates including several aliphatic and ...
Many promising drug candidates metabolized by aldehyde oxidase (AOX) fail during clinical trial owing to underestimation of their clearance. AOX is species-specific, which makes traditional… (More)