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Basal-like breast cancers have several well-characterized distinguishing molecular features, but most of these are features of the cancer cells themselves. The unique stromal-epithelial interactions, and more generally, microenvironmental features of basal-like breast cancers have not been well characterized. To identify characteristic microenvironment(More)
PURPOSE Cancer cells have altered metabolism, with increased glucose uptake, glycolysis, and biomass production. This study conducted genomic and metabolomic analyses to elucidate how tumor and stromal genomic characteristics influence tumor metabolism. EXPERIMENTAL DESIGN Thirty-three breast tumors and six normal breast tissues were analyzed by gene(More)
INTRODUCTION Overall survival of early-stage breast cancer patients is similar for those who undergo breast-conserving therapy (BCT) and mastectomy; however, 10% to 15% of women undergoing BCT suffer ipsilateral breast tumor recurrence. The risk of recurrence may vary with breast cancer subtype. Understanding the gene expression of the cancer-adjacent(More)
Basal-like and luminal breast cancers have distinct stromal–epithelial interactions, which play a role in progression to invasive cancer. However, little is known about how stromal–epithelial interactions evolve in benign and pre-invasive lesions. To study epithelial–stromal interactions in basal-like breast cancer progression, we cocultured reduction(More)
A gene expression signature indicative of activated wound responses is common to more than 90% of non-neoplastic tissues adjacent to breast cancer, but these tissues also exhibit substantial heterogeneity. We hypothesized that gene expression subtypes of breast cancer microenvironment can be defined and that these microenvironment subtypes have clinical(More)
Patricia Casbas-Hernandez, Xuezheng Sun, Erick Roman-Perez, Monica D’Arcy, Rupninder Sandhu, Asahi Hishida, Kirk K. McNaughton, Xiaohong R. Yang, Liza Makowski , Mark E. Sherman, Jonine D. Figueroa, Melissa A.Troester* 1 Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 2(More)
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