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The expression of phenotypic drug resistance or drug tolerance serves as a strategy for Mycobacterium tuberculosis to survive in vivo antimicrobial drug treatment; however, the mechanisms are poorlyContinue Reading
  • Akinori Okano, Atsushi Nakayama, +5 authors Dale L. Boger
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 18 March 2015
  • Full details of studies are disclosed on the total syntheses of binding pocket analogues of vancomycin bearing the peripheral L-vancosaminyl-1,2-D-glucosyl disaccharide that contain changes to a keyContinue Reading
  • Timothy Nguyen, Meghan S Blackledge, +7 authors Christian Melander
  • Chemistry, Medicine
  • Angewandte Chemie
  • 27 March 2017
  • A library of 2-aminobenzimidazole derivatives was screened for the ability to suppress β-lactam resistance in Mycobacterium smegmatis. Several non-bactericidal compounds were identified that reversedContinue Reading
  • Steven A. Rogers, Erick Allen Lindsey, Daniel C. Whitehead, Trey C Mullikin, Christian Melander
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 February 2011
  • The successful marriage of structural features from our 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilmContinue Reading
  • Joanne Bl Tan, Ada Chen, +7 authors Juan C. Jaén
  • Biology
  • 1 February 2017
  • Introduction: The intra-tumoral generation of adenosine (ADO), a potent inhibitor of T-cell activation, depends on the coordinated and sequential cleavage of extracellular adenosine triphosphateContinue Reading