Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki < 10 nM) and blocks CRF-stimulated adenylate cyclase activity in membranes prepared from rat cortex and pituitary. Systemically administered CP-154,526… (More)
SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse biochemical, physiological and behavioral effects induced by cannabinoid agonists. The present experiments characterized the activity of SR141716A (SR) in behavioral procedures designed to assess its… (More)
The unified probabilistic theory of indicative and counterfactual conditionals proposed by Kaufmann (2005) leads to apparently conflicting predictions about the probabilities of indicatives. We present experimental data which show that these predictions are not only not at odds with the theory, but in fact reveal a real and rarely discussed ambiguity.