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Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus
TLDR
DDEFB103 influences pro-inflammatory activities with the concentration of DEFB103 and order of timing of DEFb103 exposure to dendritic cells, being paramount in orchestrating the onset, magnitude, and composition of the chemokine and cytokine response. Expand
Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses
TLDR
It is hypothesized that histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and attenuates HagB-induced chemokine responses in human myeloid dendritic cells, which may help control oral inflammation. Expand
A cross-sectional assessment of biomarker levels around implants versus natural teeth in periodontal maintenance patients.
TLDR
The results of this study point to the differential expression of specific biomarkers in GCF versus their levels in PISF in periodontal maintenance patients, which is critical information before establishing P ISF as a diagnostic fluid to monitor peri-implant health. Expand
Comparison of pro-inflammatory cytokines and bone metabolism mediators around titanium and zirconia dental implant abutments following a minimum of 6 months of clinical function.
TLDR
No significant differences in pro-inflammatory cytokine or bone metabolism mediator profiles were observed biochemically, with the exception of leptin, for the abutment biomaterials of titanium or zirconia, and molecular PICF findings support the observed clinical biocompatibility of both titanium and zIRconia abutments. Expand
Iowa nursing facility oral hygiene (INFOH) intervention: A clinical and microbiological pilot randomized trial
TLDR
Recruitment and retention posed a significant challenge to this trial, even with a relatively short observation period, and results did not encourage further investigation of this customized oral hygiene protocol. Expand
Body fat indices and biomarkers of inflammation: a cross-sectional study with implications for obesity and peri-implant oral health.
TLDR
A modest but statistically significant positive correlation was observed between the levels of IL-1β, a major proinflammatory cytokine in PISF, and WC, a reliable measure of central obesity in stable periodontal maintenance patients. Expand
Novel biomarkers of periodontitis and/or obesity in saliva-An exploratory analysis.
TLDR
Levels of four novel biomarkers of periodontitis were detectable in saliva of subjects enrolled in a periodontal maintenance program and Prospective studies with larger sample sizes and other populations are warranted to explore the diagnostic applicability of these markers. Expand
Human β-defensin-3 alters, but does not inhibit, the binding of Porphyromonas gingivalis haemagglutinin B to the surface of human dendritic cells.
TLDR
Results suggest that HBD3 binding to rHagB alters, but does not inhibit, the binding of rHAGB to human myeloid dendritic cells. Expand
Systemic health characteristics and self-reported xerostomia among nursing facility residents in Iowa-US and Sao Paulo-Brazil
TLDR
Iowans presented with higher numbers of comorbidities and prescription medications, however xerostomia was reported in a greater percentage in SP, and was associated to higher number of medications in Iowa, but not in SP. Expand
Predicting Non-Responders to Immunotherapy Treatments through Simulation of NGS Information
TLDR
Personalized methodologies to predict a response to PD-L1/PD-1 inhibitors based on two factors are developed, which is a function of bio-markers representing immune evasion, immune activation, metastasis, and dendritic cell infiltration in cancer cells. Expand