Erica Di Cesare

Learn More
Inhibition of Aurora kinase activity by small molecules is being actively investigated as a potential anti-cancer strategy. A successful therapeutic use of Aurora inhibitors relies on a comprehensive understanding of the effects of inactivating Aurora kinases on cell division, a challenging aim given the pleiotropic roles of those kinases during mitosis.(More)
Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division. The final fates of microtubule-inhibited cells are however often heterogeneous and difficult to predict. While recent work has provided insight into the cell response to(More)
Research in our lab aims at understanding the mechanisms through which the Aurora-A/TPX2 complex regulates the fidelity of chromosome segregation at mitosis and how altered levels of the complex contribute to tumorigenesis. Mitotic spindle function ensures the fidelity of chromosome segregation; spindle defects generate genetically unbalanced(More)
  • 1