Erica Di Cesare

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Inhibition of Aurora kinase activity by small molecules is being actively investigated as a potential anti-cancer strategy. A successful therapeutic use of Aurora inhibitors relies on a comprehensive understanding of the effects of inactivating Aurora kinases on cell division, a challenging aim given the pleiotropic roles of those kinases during mitosis.(More)
Research in our lab aims at understanding the mechanisms through which the Aurora-A/TPX2 complex regulates the fidelity of chromosome segregation at mitosis and how altered levels of the complex contribute to tumorigenesis. Mitotic spindle function ensures the fidelity of chromosome segregation; spindle defects generate genetically unbalanced(More)
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