Erica Di Cesare

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Inhibition of Aurora kinase activity by small molecules is being actively investigated as a potential anti-cancer strategy. A successful therapeutic use of Aurora inhibitors relies on a comprehensive understanding of the effects of inactivating Aurora kinases on cell division, a challenging aim given the pleiotropic roles of those kinases during mitosis.(More)
  • D. Villari, S. Spinella, +4 authors G. Raimondo
  • 1995
We report a case of ductopenia associated with cholestatic hepatitis in a 59-year-old woman treated for 41 years for temporal epilepsy. The patient developed jaundice, without any clinical or biochemical features of hypersensitivity, 10 months after the beginning of treatment with sulpiride. Liver biopsy showed ballooning and acidophilic degeneration of the(More)
Tubulin-targeting molecules are widely used cancer therapeutic agents. They inhibit microtubule-based structures, including the mitotic spindle, ultimately preventing cell division. The final fates of microtubule-inhibited cells are however often heterogeneous and difficult to predict. While recent work has provided insight into the cell response to(More)
Research in our lab aims at understanding the mechanisms through which the Aurora-A/TPX2 complex regulates the fidelity of chromosome segregation at mitosis and how altered levels of the complex contribute to tumorigenesis. Mitotic spindle function ensures the fidelity of chromosome segregation; spindle defects generate genetically unbalanced(More)
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