Transient receptor potential (TRP) channels have been increasingly implicated in the pathological mechanisms of CNS disorders. TRP expression has been detected in neurons, astrocytes, oligodendrocytes, microglia, and ependymal cells as well as in the cerebral vascular endothelium and smooth muscle. In stroke, TRPC3/4/6, TRPM2/4/7, and TRPV1/3/4 channels… (More)
—A 14.025 Gb/s multi-media transceiver employs on-die Rx AC coupling with baseline wander correction and equalizes up to 26 dB insertion loss at 14.025 Gb/s with a linear equalizer, 10-tap DFE, and 4-tap Tx FIR filter in SST driver. The proposed techniques enable direct feedback for 1st-tap ISI cancellation , and positions of four DFE taps to be adapted… (More)
Measurement of NO and/or its metabolites in the various body compartments has transformed our understanding of biology. The inability of the current NO measurement methods to account for naturally occurring and experimental NO isotopes, however, has prevented the scientific community from fully understating NO metabolism in vivo. Here we present a mid-IR… (More)
The aging myopathy manifests itself with diastolic dysfunction and preserved ejection fraction. We raised the possibility that, in a mouse model of physiological aging, defects in electromechanical properties of cardiomyocytes are important determinants of the diastolic characteristics of the myocardium, independently from changes in structural composition… (More)
Nab-paclitaxel has recently shown greater efficacy in pancreatic ductal adenocarcinoma (PDAC). Insulin like growth factor (IGF) signaling proteins are frequently overexpressed in PDAC and correlate with aggressive tumor phenotype and poor prognosis. We evaluated the improvement in nab-paclitaxel response by addition of BMS-754807, a small molecule inhibitor… (More)
We have developed a transportable spectroscopic nitrogen isotopic analyzer. The spectrometer is based on dual-modulation Faraday rotation spectroscopy of nitric oxide isotopologues with near shot-noise limited performance and baseline-free operation. Noise analysis indicates minor isotope ((15)NO) detection sensitivity of 0.36 ppbv·Hz(-1/2), corresponding… (More)
A dual-modulation Faraday rotation spectrometer is employed for isotopic ratiometry of nitric oxide (NO) converted from nitrate/nitrite. Excellent linearity of measured NO to dissolved nitrate is demonstrated. Ratiometry of IAEA-NO-3 standards indicates ~3 % accuracy.
—Multiple accesses are common for most mobile devices today. This technological advance opens up a new design space for improving the communication performance of mobile devices. Multipath TCP is a TCP extension that enables using multiple network paths between two end systems for a single TCP connection, increasing performance and reliability. Meanwhile,… (More)