Eric Y. Kim

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Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O(6)-methylguanine-DNA methyltransferase (MGMT). Wild-type (wt) p53 was previously shown to down-modulate MGMT. However, p53 therapy for GBM is limited by lack of efficient delivery across the blood brain barrier (BBB). We have developed a systemic nanodelivery(More)
In condition monitoring of low speed rolling element bearings (REBs), traditional techniques involving vibration acceleration may not be able to detect a growing fault due to the low impact energy generated by the relative motion of the components. This study presents an experimental evaluation for incipient fault detection of low speed REBs by using an(More)
In condition-based maintenance (CBM), effective diagnostics and prognostics are essential tools for maintenance engineers to identify imminent fault and to predict the remaining useful life before the components finally fail. This enables remedial actions to be taken in advance and reschedules production if necessary. This paper presents a technique for(More)
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