Eric Vandervoort

Learn More
Deviations in reward sensitivity and behavioral flexibility, particularly in the ability to change or stop behaviors in response to changing environmental contingencies, are important phenotypic dimensions of several neuropsychiatric disorders. Neuroimaging evidence suggests that variation in dopamine signaling through dopamine D(2)-like receptors may(More)
We investigated the accuracy of qSPECT, a quantitative SPECT reconstruction algorithm we have developed which employs corrections for collimator blurring, photon attenuation and scatter, and provides images in units of absolute radiotracer concentrations (kBq cm(-3)). Using simulated and experimental phantom data with characteristics similar to clinical(More)
The attenuation corrections factors (ACFs), which are necessary for quantitatively accurate PET imaging, can be obtained using singles-mode transmission scanning. However, contamination from scatter is a largely unresolved problem for these data. We present an extension of the Monte Carlo simulation tool, GATE, for singles-mode transmission data and its(More)
UNLABELLED In previous work, we described and validated a method of scatter correction for singles-mode transmission data using experimental preinjection data acquired with a dedicated rodent PET scanner. In the current work, we investigated the impact that our method has on the quantitative accuracy of small-animal PET. METHODS This investigation had 3(More)
We present an analytical scatter correction, based upon the Klein-Nishina formula, for singles-mode transmission data in positron emission tomography (PET) and its implementation as part of an iterative image reconstruction algorithm. We compared our analytically-calculated scatter sinogram data with previously validated simulation data for a small animal(More)
  • 1