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Tonic motor control involves oscillatory synchronization of activity at low frequency (5-30 Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the mechanisms underpinning cerebellar oscillations. We found that Golgi interneurons, which gate information transfer in the cerebellar cortex input layer, are extensively coupled(More)
OBJECTIVE To perform an evidence-based review of the literature on neuroimaging techniques utilized in spinal cord injury clinical practice and research. METHODS A search of the medical literature for articles on specific neuroimaging techniques used in SCI resulted in 2,302 published reports. Review at the abstract and full report level yielded 99(More)
Central pattern generators are networks of neurons capable of generating an output pattern of spike activity in a relatively stereotyped, rhythmic pattern that has been found to underlie vital functions like respiration and locomotion. The central pattern generator for locomotion in vertebrates seems to share some basic building blocks. Activation and(More)
This paper describes the system design developed for Team Gator Nation's submission to the 2007 DARPA Urban Challenge. In this event, vehicles had to navigate on city streets while obeying basic traffic laws. One of the major challenges was interacting with other vehicles such as at intersections. To address these challenges, a hybrid Toyota Highlander was(More)
This paper reports the results of a four-year National Science Foundation CCLI grant that supported development and assessment of curricular material linking computer science (CS), digital audio, music, and sound design. A book and online learning aids were created and used in courses and summer workshops. The material was refined based on feedback from(More)
The attenuation of neuronal voltage responses to high-frequency current inputs by the membrane capacitance is believed to limit single-cell bandwidth. However, neuronal populations subject to stochastic fluctuations can follow inputs beyond this limit. We investigated this apparent paradox theoretically and experimentally using Purkinje cells in the(More)
Understanding how neuromodulators regulate behavior requires investigating their effects on functional neural systems, but also their underlying cellular mechanisms. Utilizing extensively characterized lamprey motor circuits, and the unique access to reticulospinal presynaptic terminals in the intact spinal cord that initiate these behaviors, we(More)
Neurotransmitters are thought to be released as quanta, where synaptic vesicles deliver packets of neurotransmitter to the synaptic cleft by fusion with the plasma membrane. However, synaptic vesicles may undergo incomplete fusion. We provide evidence that G protein-coupled receptors inhibit release by causing such incomplete fusion. 5-hydroxytryptamine(More)
Sliding-window applications, an important class of the digital-signal processing domain, are highly amenable to pipeline parallelism on field-programmable gate arrays (FPGAs). Although memory bandwidth often restricts parallelism for many applications, sliding-window applications can leverage custom buffers, referred to as sliding-window generators, that(More)
BACKGROUND Irreversible electroporation (IRE) is a relatively new approach to the management of multiple types of locally advanced soft tissue tumors. Unique peri-procedural anesthetic management is needed in the safe and effective delivery of this therapy. OBJECTIVES This study analyzed IRE therapy in relation to anesthetic management for our initial(More)