Eric Sandler

Michael S. Isakoff1
Richard M. Lush1
Anthony M. Neuger1
1Michael S. Isakoff
1Richard M. Lush
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  • Damon R. Reed, Leo Mascarenhas, Kathleen Manning, Gregory A. Hale, John Goldberg, Jonathan Gill +9 others
  • 2016
Targeted kinase inhibitors and camptothecins have shown preclinical and clinical activity in several cancers. This trial evaluated the maximum tolerated dose (MTD) and dose-limiting toxicities of sorafenib and topotecan administered orally in pediatric patients with relapsed solid tumors. Sorafenib was administered twice daily and topotecan once daily on(More)
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