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  • Richard Eric Mewshaw, Stephen Marc Bowen, Heather A. Harris, Zhang Bao Xu, Eric S. Manas, Stephen Todd Cohn
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 February 2007)
  • A series of 4'-hydroxyphenyl-aryl-carbaldehyde oximes (5b) was prepared and found to have high affinity (4nM) and modest selectivity (39-fold) for estrogen receptor-beta (ERbeta). Substitution of oneExpand
  • Paweł Nowak, Derek Cecil Cole, +21 authors John Watson Ellingboe
  • Medicine, Chemistry
  • Bioorganic & medicinal chemistry letters
  • 2010 (First Publication: 15 January 2010)
  • 8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (1) was identified through HTS, as a weak (micromolar) inhibitor of BACE1. X-Ray crystallographic studies indicate the 2-aminoimidazoleExpand