Eric S. Underbakke

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Characterizing protein-protein interactions in a biologically relevant context is important for understanding the mechanisms of signal transduction. Most signal transduction systems are membrane associated and consist of large multiprotein complexes that undergo rapid reorganization--circumstances that present challenges to traditional structure(More)
We report a general method for the solid-phase synthesis of polymers via the ring-opening metathesis polymerization (ROMP). The method involves polymerization in solution to form a block copolymer, immobilization of the polymer via reaction of one block with a resin-bound functional group, modification of the other block, and liberation of the polymer from(More)
Fundamental to our understanding of biological systems is the ability to define interaction surfaces and conformational changes in dynamic protein complexes, yet this objective remains a challenge. Protein footprinting is a powerful solution to this problem. Methods such as hydrogen–deute-rium exchange, [1] limited proteolysis, [2] and radiolytic cleav-age(More)
Advances in genomic and proteomic methods provide the means to ascertain not only what receptors are present in a given cell but also how prevalent they are. While it is reasonable to assume that receptor concentration has a critical role in cell physiology, a new study published in this issue of The EMBO Journal suggests that the more relevant parameter(More)
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