Eric S. Lee

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T he excitement of scientifi c research and discovery cannot be fully conveyed by didactic lectures alone. Several recent initiatives and proposals, therefore, have supported a more participatory, discovery-based instruction for undergraduate science education [1,2]. In functional genomics, we have found an ideal platform to simultaneously benefi t students(More)
Correct suspect identification of known offenders by witnesses deteriorates rapidly as more are examined in mugshot albums. Feature approaches, where mugshots are displayed in order of similarity to witnesses' descriptions, attempt to increase identification success by reducing this number. A methodology is proposed for system design and evaluation based on(More)
Glycogen storage disease type II (GSDII) is a recessively inherited disorder caused by defects in lysosomal acid alpha-glucosidase. In an attempt to reproduce the range of clinical manifestations of the human illness we have created null alleles at the acid alpha-glucosidase locus (GAA) with several gene targeting strategies. In each knockout strain, enzyme(More)
BACKGROUND The authors previously reported the generation of a knockout mouse model of Pompe disease caused by the inherited deficiency of lysosomal acid alpha-glucosidase (GAA). The disorder in the knockout mice (GAA-/-) resembles the human disease closely, except that the clinical symptoms develop late relative to the lifespan of the animals. In an(More)
or Children's Hospital of New Orleans. The 8-week summer research program allows students to cultivate their interest in pursuing research careers in either basic or clinical sciences. During the program students conduct their own small research project or work on part of an ongoing research project. Drs. Gregory and Tsien would like to extend their special(More)
A 52-year-old man presented with sudden onset of acral paresthesia and imbalance. The patient did not have any recent illness, sick contacts, or travel abroad. He denied weakness, pain, bowel or bladder incontinence, dysphagia, dysarthria, or shortness of breath. On neurologic examination, 1 month into his symptoms, he had reduced muscle strength in his(More)