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In this paper, an optimization-based approach is proposed using a mixed integer quadratic programming model for the economic dispatch of electrical power generators with prohibited zones of operation. The main advantage of the proposed approach is its capability to solve case studies from the literature to global optimality quickly and without any targeting(More)
OBJECTIVE To determine whether immunization of HLA-B27 transgenic mice with a peptide containing the crossreactive QTDRED sequence found in B2705 and Klebsiella nitrogenase induces a detectable immune response. METHODS Mice were immunized with a synthesized peptide corresponding to the 65-84 region of HLA-B2705 in Freund's complete adjuvant (FCA). Mice(More)
The B10.A T cell proliferative response to pigeon cytochrome c is mainly directed against a single antigenic determinant located at the carboxy-terminal end of the molecule. In the present experiments, we used synthetic peptide analogs of the carboxy-terminal sequence of moth cytochrome c to explore the structural requirements for antigenic potency. The(More)
The dominant T cell determinant on moth and pigeon cytochromes c in B10.A (E beta k:E alpha k) mice is located in the C-terminal portion of the protein, contained within residues 93-103 or 93-104. Thirty-seven antigen analogs, containing single amino acid substitutions at positions 98, 99, 101, 102, 103, and 104, were synthesized. The effects of the(More)
T cell reactivity toward self MHC class II molecules has been recognized in syngeneic MLR in a number of studies, where the T cells are believed to recognize the combination of self/nonself peptide and self MHC molecule. We investigated the stimulation of T cell proliferation by synthetic peptides of sequences corresponding to the first polymorphic amino(More)
Peptides eluted from murine Major Histocompatibility Complex (MHC) class II molecules are predominantly fragments of self proteins, which include apolipoprotein E, cystatin-c, transferrin receptor, MHC class II and Ii chains. These naturally processed self peptides are expected to be presented during ontogeny. Therefore, immune responses to these peptides(More)
MHC class I and class II molecules present peptide Ag to T lymphocytes. Peptides are critical in class I heavy chain folding and/or stable association with beta 2m. A recent study suggests the role of peptide Ag binding for MHC class II alpha- and beta-chain heterodimers to enter into a compact state and allow their transport to the cell surface. We have(More)
Several lines of evidence support the concept of two functionally distinct sites on antigen: the epitope, involved in interaction with the T cell receptor and the agretope, interacting with Ia. We investigated the Ia and T cell receptor interaction sites on the synthetic polypeptide antigen poly-18 [poly-EYK(EYA)5] using T cell hybridoma clones specific for(More)
T cells bearing certain variable (V) regions of the T cell receptor (TcR), including V beta 3, V beta 6, V beta 8.1 and V beta 9, are stimulated by one or more forms of the endogenous superantigen, mouse lymphocyte stimulatory (Mls) locus, encoded by the mouse mammary tumor virus, in the context of a non-polymorphic region of the class II molecules of the(More)