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The experiments reported here identify nitric oxide as a molecular effector of activated macrophage induced cytotoxicity. Cytotoxic activated macrophages synthesize nitric oxide from a terminal guanidino nitrogen atom of L-arginine which is converted to L-citrulline without loss of the guanidino carbon atom. In addition, authentic nitric oxide gas causes(More)
Three-dimensional (3D) shape models are powerful because they enable the inference of object shape from incomplete, noisy, or ambiguous 2D or 3D data. For example, realistic parameterized 3D human body models have been used to infer the shape and pose of people from images. To train such models, a corpus of 3D body scans is typically brought into(More)
Isotope dilution gas chromatography-mass spectrometry analysis of genomic DNAs isolated from the different growth phases of Neurospora crassa revealed significant differences in the amounts of 5-methylcytosine; the mol % of 5-methylcytosine was 0.36 in conidia (asexual spores), 0.40 in conidial germlings cultured for 3 h, 0.24 in mycelial cells that had(More)
Peer-to-peer systems have been proposed for a wide variety of applications, including file-sharing, web caching, distributed computation, cooperative backup, and onion routing. An important motivation for such systems is self-scaling. That is, increased participation increases the capacity of the system. Unfortunately, this property is at risk from selfish(More)
Exploiting the high-potential of nanoscale architectures requires that they be controlled by CMOS technology. Such an interface, a decoder, must control many nanowires (NWs) with a small number of meso-scale wires (MWs). Multiple types of decoder have been proposed, each of which can be modelled as embedding resistive switches in NWs. In this paper we(More)
[reaction: see text] Further oxidation of the common DNA lesion 8-oxo-7,8-dihydroguanosine by one-electron oxidants such as IrCl6(2-), Fe(CN)6(3-), or SO4-* leads to two major products, depending upon reaction conditions. In nucleosides at pH 7, 22 degrees C, the principal product is shown herein to be a spiroiminodihydantoin nucleoside, as a diastereomeric(More)
Use of one-electron oxidants such as Na(2)IrCl(6) to oxidize 8-oxo-7,8-dihydro-2'-deoxyguanosine (OG) residues in oligodeoxynucleotides was previously shown to lead to predominant formation of a base lesion of mass M - 10 compared to starting material [Duarte et al. (1999) Nucleic Acids Res. 27, 596-502]. To thoroughly characterize the structure of this(More)
Isotope dilution gas chromatography-mass spectrometry analysis of genomic DNAs isolated from three Candida albicans isolates showed significant differences in the amounts of 5-methyldeoxycytidine (m5Cyt) in DNA from yeast-form and from mycelial-form cells; the moles percent m5Cyt were 0.11, 0.11, and 0.097 for yeast-form DNA and 0.045, 0.053, and 0.047 for(More)
A key challenge facing nanotechnologies is learning to control uncertainty introduced by stochastic self-assembly. In this article, we explore architectural and manufacturing strategies to cope with this uncertainty when assembling nanoarrays, crossbars composed of two orthogonal sets of parallel nanowires (NWs) that are differentiated at their time of(More)