Eric Parker

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Voxel-based modeling techniques are known for their robustness and flexibility. However, they have three major shortcomings: (1) Memory intensive, since a large number of voxels are needed to represent high-resolution models (2) Computationally expensive, since a large number of voxels need to be visited (3) Computationally expensive isosurface extraction(More)
The Graphplan algorithm exemplifies the speed-up achieveable with disjunctive representations that leverage opposing directions of refinement. It is in this spirit that we introduce Bsr-graphplan, a work in progress intended to address issues of scalability and expressiveness which are problematic for Graphplan. Specifically, we want to endow the planner(More)
Neuropeptide Y is a widely distributed neuropeptide that elicits a plethora of physiological effects via interaction with six different receptors (Y(1)-y(6)). Recent attention has focused on the role of neuropeptide Y in the regulation of energy homeostasis. Neuropeptide Y stimulates food intake, inhibits energy expenditure, increases body weight and(More)
The neuropeptide Y (NPY) Y(5) receptor is believed to be involved in the central regulation of appetite. Thus, antagonists of this receptor have been pursued as potential therapeutic agents for the treatment of obesity. A novel series of potent and selective phenylamide or biaryl urea NPY Y(5) receptor antagonists was identified. Four representative(More)
During the past few decades advances in semiconductor technology have had only modest implications for the design and verification of integrated systems. While "deep-submicron" effects created new challenges for guaranteeing electrical integrity and necessitated the bundling of traditionally separated design steps such as logic synthesis and physical(More)
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