• Publications
  • Influence
Passage of Heme-Iron Across the Envelope of Staphylococcus aureus
The cell wall envelope of Gram-positive pathogens functions as a scaffold for the attachment of virulence factors and as a sieve that prevents diffusion of molecules. Here the isdgenesExpand
  • 407
  • 29
  • PDF
Nutritional immunity: transition metals at the pathogen–host interface
Transition metals occupy an essential niche in biological systems. Their electrostatic properties stabilize substrates or reaction intermediates in the active sites of enzymes, and their heightenedExpand
  • 800
  • 21
IsdG and IsdI, Heme-degrading Enzymes in the Cytoplasm of Staphylococcus aureus*
Staphylococcus aureus requires iron for growth and utilizes heme as a source of iron during infection. Staphylococcal surface proteins capture hemoglobin, release heme from hemoglobin and transportExpand
  • 253
  • 21
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Bacterial infection often results in the formation of tissue abscesses, which represent the primary site of interaction between invading bacteria and the innate immune system. We identify the hostExpand
  • 621
  • 20
Iron in infection and immunity.
Iron is an essential nutrient for both humans and pathogenic microbes. Because of its ability to exist in one of two oxidation states, iron is an ideal redox catalyst for diverse cellular processesExpand
  • 578
  • 20
The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts
Iron is a vital nutrient for virtually all forms of life. The requirement for iron is based on its role in cellular processes ranging from energy generation and DNA replication to oxygen transportExpand
  • 556
  • 20
  • PDF
Iron-Source Preference of Staphylococcus aureus Infections
Although bacteria use different iron compounds in vitGro, the possibility that microbes distinguish between these iron sources during infection has hitherto not been examined. We applied stableExpand
  • 354
  • 16
  • PDF
Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization.
The pathogenesis of human infections caused by the gram-positive microbe Staphylococcus aureus has been previously shown to be reliant on the acquisition of iron from host hemoproteins. TheExpand
  • 249
  • 15
  • PDF
Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens
ABSTRACT Virtually all bacterial pathogens require iron to infect vertebrates. The most abundant source of iron within vertebrates is in the form of heme as a cofactor of hemoproteins. Many bacterialExpand
  • 211
  • 14
Molecular mechanisms of Staphylococcus aureus iron acquisition.
The unique redox potential of iron makes it an ideal cofactor in diverse biochemical reactions. Iron is therefore vital for the growth and proliferation of nearly all organisms, including pathogenicExpand
  • 238
  • 13